TY - JOUR
T1 - Stem cell applications for treatment of cancer and autoimmune diseases
T2 - Its promises, obstacles, and future perspectives
AU - Hawsawi, Yousef M.
AU - Al-Zahrani, Faisal
AU - Mavromatis, Charalampos Harris
AU - Baghdadi, Mohammed A.
AU - Saggu, Shalini
AU - Oyouni, Atif Abdulwahab A.
N1 - Publisher Copyright:
© The Author(s) 2018.
PY - 2018/1
Y1 - 2018/1
N2 - Since the original discovery of stem cells, a new era of promising results has emerged in the clinical application of stem cells for the treatment of several important diseases, including cancer and autoimmune diseases. The plentiful research on stem cells during the past decades has provided significant information on the developmental, morphological, and physiological processes that govern tissue and organ formation, maintenance, and regeneration; cellular differentiation; molecular processes; and tissue homeostasis. In this review, we present the history of the use of stem cells in different clinical applications. Furthermore, we discuss the various therapeutic options for stem cells in cancer, followed by the role of stem cells in the treatment of autoimmune disorders. Additionally, we highlight the risks of and obstacles to the application of stem cells in clinical practice. Ultimately, we show future perspectives in stem cell use, with an aim to improve the clinical usefulness of stem cells.
AB - Since the original discovery of stem cells, a new era of promising results has emerged in the clinical application of stem cells for the treatment of several important diseases, including cancer and autoimmune diseases. The plentiful research on stem cells during the past decades has provided significant information on the developmental, morphological, and physiological processes that govern tissue and organ formation, maintenance, and regeneration; cellular differentiation; molecular processes; and tissue homeostasis. In this review, we present the history of the use of stem cells in different clinical applications. Furthermore, we discuss the various therapeutic options for stem cells in cancer, followed by the role of stem cells in the treatment of autoimmune disorders. Additionally, we highlight the risks of and obstacles to the application of stem cells in clinical practice. Ultimately, we show future perspectives in stem cell use, with an aim to improve the clinical usefulness of stem cells.
KW - Autoimmune disease
KW - Cancer
KW - Clinical advances
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=85055073515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055073515&partnerID=8YFLogxK
U2 - 10.1177/1533033818806910
DO - 10.1177/1533033818806910
M3 - Review article
C2 - 30343639
AN - SCOPUS:85055073515
SN - 1533-0346
VL - 17
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
ER -
