Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies

Goran Rakocevic, Raghavan Raju, Cristina Semino-Mora, Marinos C. Dalakas

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


We report five of 38 patients with stiff person syndrome (SPS), who also had cerebellar disease, gait ataxia, dysarthria, and oculomotor dysfunction (SPS-Cer). Cerebellar manifestations either preceded SPS or occurred concurrently. Brain MRI was normal. The intrathecal production of glutamic acid decarboxylase antibodies was elevated. γ-Aminobutyric acid-enhancing drugs and immunotherapies improved only the stiffness. SPS-Cer is a distinct subset of SPS causing a more severe and complex clinical phenotype.

Original languageEnglish (US)
Pages (from-to)1068-1070
Number of pages3
Issue number6
StatePublished - Sep 2006
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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