Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons

Yu Liu, Yan Mei Tao, Ran Sook Woo, Wencheng Xiong, Lin Mei

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Neuregulin-1 (NRG1) plays an important role in neural development, synapse formation, and synaptic plasticity by activating ErbB receptor tyrosine kinases. Although ligand-induced endocytosis has been shown to be important for many receptor tyrosine kinases, whether NRG1 signaling depends on ErbB endocytosis remains controversial. Here, we provide evidence that ErbB4, a prominent ErbB protein in the brain, becomes internalized in NRG1-stimulated neurons. The induced ErbB4 endocytosis requires its kinase activity. Remarkably, inhibition of ErbB endocytosis attenuates NRG1-induced activation of Erk and Akt in neurons. These observations indicate a role of ErbB endocytosis in NRG1 signaling in neurons.

Original languageEnglish (US)
Pages (from-to)505-510
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Mar 9 2007


  • Biotinylation
  • Endocytosis
  • ErbB4
  • Internalization
  • Neuregulin
  • Neurons
  • Schizophrenia
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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