@article{b119c1ce63354a3baea2efcedbd48619,
title = "Stimuli-responsive transdermal microneedle patches",
abstract = "Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action toward different indications. Future opportunities and challenges with respect to clinical translation are also discussed.",
author = "Pooyan Makvandi and Rezvan Jamaledin and Guojun Chen and Zahra Baghbantaraghdari and Zare, {Ehsan Nazarzadeh} and {Di Natale}, Concetta and Valentina Onesto and Raffaele Vecchione and Jesse Lee and Tay, {Franklin R.} and Paolo Netti and Virgilio Mattoli and Ana Jaklenec and Zhen Gu and Robert Langer",
note = "Funding Information: C. Di Natale was supported by Fondazione Umberto Veronesi Post-Doctoral Fellowship 2021. Z. Gu was supported by the grants from National Institutes of Health (NIH) (grant no. R01 DK112939 01A1), National Science Foundation (grant no. 1708620), and American Diabetes Association (grant no. 1‐15‐ACE‐21). G. Chen was also supported by the Start-up package form McGill University. Z.G. is a scientific co-founder of Zenomics Inc. and Zcapsule Inc. R.L. is a scientific advisor to Zenomic Inc. and Zcapsule Inc. For a list of entities with which R.L. is involved, compensated or uncompensated, see https://tinyurl.com/RLCOINBME. The remaining authors declare no competing interests. Funding Information: C. Di Natale was supported by Fondazione Umberto Veronesi Post-Doctoral Fellowship 2021. Z. Gu was supported by the grants from National Institutes of Health (NIH) (grant no. R01 DK112939 01A1 ), National Science Foundation (grant no. 1708620 ), and American Diabetes Association (grant no. 1‐15‐ACE‐21 ). G. Chen was also supported by the Start-up package form McGill University. Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = jul,
day = "1",
doi = "10.1016/j.mattod.2021.03.012",
language = "English (US)",
volume = "47",
pages = "206--222",
journal = "Materials Today",
issn = "1369-7021",
publisher = "Elsevier",
}