Stimuli-responsive transdermal microneedle patches

Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations


Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action toward different indications. Future opportunities and challenges with respect to clinical translation are also discussed.

Original languageEnglish (US)
Pages (from-to)206-222
Number of pages17
JournalMaterials Today
StatePublished - Jul 1 2021

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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