We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Bacteriology|
|State||Published - Jan 2009|
ASJC Scopus subject areas
- Molecular Biology