Stromal-epithelial interaction in prostate cancer progression

Leland W.K. Chung; Wen Chin Huang; Shian Ying Sung; Daqing Wu; Valerie Odero-Marah; Takeo Nomura; Katsumi Shigemura; Tohru Miyagi; Seogil Seo; Chumeng Shi; Joe Molitierno; James Elmore; Cynthia Anderson; Shuji Isotani; Magnus Edlund; Chia Ling Hsieh; Ruoxiang Wang; Bahig Shehata; Haiyen E. Zhau

doi:10.3816/CGC.2006.n.034

Stromal-epithelial interaction in prostate cancer progression

Leland W.K. Chung, Wen Chin Huang, Shian Ying Sung, Daqing Wu, Valerie Odero-Marah, Takeo Nomura, Katsumi Shigemura, Tohru Miyagi, Seogil Seo, Chumeng Shi, Joe Molitierno, James Elmore, Cynthia Anderson, Shuji Isotani, Magnus Edlund, Chia Ling Hsieh, Ruoxiang Wang, Bahig Shehata, Haiyen E. Zhau

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Cancer is not a single-cell disease, and its existence and behavior are constantly modulated by the host. Cancer gene expression and genetics are also highly dynamic and are regulated epigenetically by the host through gene-environment interaction. In this article, we describe the molecular pathways leading to an unusual property of cancer cells: the ability to mimic the host microenvironment and, in particular, the characteristics of osteomimicry and vasculogenic mimicry, which are likely to be regulated by soluble and insoluble factors in the tumor-adjacent microenvironment. We also discuss the importance of host inflammatory and stem cells that contribute to the growth and survival of cancer cells. By understanding the salient features of cancer-host interaction, novel therapeutics might be developed to target the cancer and its host in the treatment of lethal prostate cancer metastases.

Original language	English (US)
Pages (from-to)	162-170
Number of pages	9
Journal	Clinical Genitourinary Cancer
Volume	5
Issue number	2
DOIs	https://doi.org/10.3816/CGC.2006.n.034
State	Published - 2006
Externally published	Yes

Keywords

Androgen-independent progression
Bone metastases
Cell signaling
Epithelial to mesenchymal transition
Extracellular matrices
Growth factors
Inflammation
Osteomimicry
Stem cells
Tumor stromal interaction

ASJC Scopus subject areas

Oncology
Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3816/CGC.2006.n.034

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Chung, L. W. K., Huang, W. C., Sung, S. Y., Wu, D., Odero-Marah, V., Nomura, T., Shigemura, K., Miyagi, T., Seo, S., Shi, C., Molitierno, J., Elmore, J., Anderson, C., Isotani, S., Edlund, M., Hsieh, C. L., Wang, R., Shehata, B., & Zhau, H. E. (2006). Stromal-epithelial interaction in prostate cancer progression. Clinical Genitourinary Cancer, 5(2), 162-170. https://doi.org/10.3816/CGC.2006.n.034

Chung, LWK, Huang, WC, Sung, SY, Wu, D, Odero-Marah, V, Nomura, T, Shigemura, K, Miyagi, T, Seo, S, Shi, C, Molitierno, J, Elmore, J, Anderson, C, Isotani, S, Edlund, M, Hsieh, CL, Wang, R, Shehata, B & Zhau, HE 2006, 'Stromal-epithelial interaction in prostate cancer progression', Clinical Genitourinary Cancer, vol. 5, no. 2, pp. 162-170. https://doi.org/10.3816/CGC.2006.n.034

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AU - Zhau, Haiyen E.

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KW - Tumor stromal interaction

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Stromal-epithelial interaction in prostate cancer progression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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