Interrupted adenylation domains are enigmatic fusions, in which one enzyme is inserted into another to form a highly unusual bifunctional enzyme. We present the first crystal structure of an interrupted adenylation domain that reveals a unique embedded methyltransferase. The structure and functional data provide insight into how these enzymes N-methylate amino acid precursors en route to nonribosomal peptides.
|Original language||English (US)|
|Number of pages||3|
|Journal||Nature Chemical Biology|
|State||Published - May 1 2018|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology