Structural considerations of autoantibodies

Michael P. Madaio, Y. Naparstek

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The mechanisms responsible for peptide-induced immunosuppression lupus-prone BWF1 mice were determined to be mediated via recognition by T cells, although the response was peptide-specific, as some accelerated the autoimmune response. Furthermore, this was associated with suppression of IFN-g and IL-4 in serum and increased TGF-b. Recent isolation of peptide-specific T cells should be helpful in sorting out the mechanisms responsible for these events. In separate studies, it was demonstrated that an anti-DNA antibody that enters cells is able to transport proteins linked to it, supporting the possibility that this system can be used as a therapeutic modality to modify specific cellular activities.

Original languageEnglish (US)
Pages (from-to)774-775
Number of pages2
Issue number12
StatePublished - Dec 1 2002
Externally publishedYes


  • Autoantibodies
  • Cytokines
  • Drug delivery
  • Immunlogic tolerance
  • T cells

ASJC Scopus subject areas

  • Rheumatology
  • General Medicine


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