Substance abuse and clozapine treatment

P. Buckley, P. A. Thompson, L. Way, H. Y. Meltzer

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Among 118 patients with DSM-III-R diagnoses of schizophrenia or schizoaffective disorder who received treatment with clozapine, 29 patients had an antecedent or current history of substance abuse. Substance abusers and nonabusers showed similar improvements on measures of psychopathology and psychosocial functioning after 6 months of clozapine therapy. The implications of this finding are discussed.

Original languageEnglish (US)
Pages (from-to)114-116
Number of pages3
JournalJournal of Clinical Psychiatry
Issue number9 SUPPL. B
StatePublished - 1994

ASJC Scopus subject areas

  • Psychiatry and Mental health


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