Survival of nerve and Schwann cells in allografts after Cyclosporin A treatment

Andrew A. Zalewski; Adarsh K. Gulati

doi:10.1016/0014-4886(80)90022-9

Survival of nerve and Schwann cells in allografts after Cyclosporin A treatment

Andrew A. Zalewski, Adarsh K. Gulati

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Because nerve and Schwann cells in allografts are rejected by normal rats, we investigated whether or not these neurological cells would survive if rats were treated with the new immunosuppressive drug, Cyclosporin A. Untreated rats rejected nerve and Schwann cells in allografts of ganglia or nerve. On the other hand, nerve and Schwann cells survived in allografts in Cyclosporin A-treated rats even after drug therapy was terminated. These results indicate that Cyclosporin A may be of value if allogenic nerve or Schwann cells are needed to aid in the repair of injured nerve tissue.

Original language	English (US)
Pages (from-to)	219-225
Number of pages	7
Journal	Experimental Neurology
Volume	70
Issue number	2
DOIs	https://doi.org/10.1016/0014-4886(80)90022-9
State	Published - Jan 1 1980
Externally published	Yes

Keywords

BN
Brown Norway
CsA
Cyclosporin A
EDL
LE
Lewis
PAS
TA
extensor digitorum longus
hematoxylin—periodic acid-Schiff-hematoxylin
tibialis anterior

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/0014-4886(80)90022-9

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title = "Survival of nerve and Schwann cells in allografts after Cyclosporin A treatment",

abstract = "Because nerve and Schwann cells in allografts are rejected by normal rats, we investigated whether or not these neurological cells would survive if rats were treated with the new immunosuppressive drug, Cyclosporin A. Untreated rats rejected nerve and Schwann cells in allografts of ganglia or nerve. On the other hand, nerve and Schwann cells survived in allografts in Cyclosporin A-treated rats even after drug therapy was terminated. These results indicate that Cyclosporin A may be of value if allogenic nerve or Schwann cells are needed to aid in the repair of injured nerve tissue.",

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AU - Zalewski, Andrew A.

AU - Gulati, Adarsh K.

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N2 - Because nerve and Schwann cells in allografts are rejected by normal rats, we investigated whether or not these neurological cells would survive if rats were treated with the new immunosuppressive drug, Cyclosporin A. Untreated rats rejected nerve and Schwann cells in allografts of ganglia or nerve. On the other hand, nerve and Schwann cells survived in allografts in Cyclosporin A-treated rats even after drug therapy was terminated. These results indicate that Cyclosporin A may be of value if allogenic nerve or Schwann cells are needed to aid in the repair of injured nerve tissue.

AB - Because nerve and Schwann cells in allografts are rejected by normal rats, we investigated whether or not these neurological cells would survive if rats were treated with the new immunosuppressive drug, Cyclosporin A. Untreated rats rejected nerve and Schwann cells in allografts of ganglia or nerve. On the other hand, nerve and Schwann cells survived in allografts in Cyclosporin A-treated rats even after drug therapy was terminated. These results indicate that Cyclosporin A may be of value if allogenic nerve or Schwann cells are needed to aid in the repair of injured nerve tissue.

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KW - EDL

KW - LE

KW - Lewis

KW - PAS

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KW - hematoxylin—periodic acid-Schiff-hematoxylin

KW - tibialis anterior

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Survival of nerve and Schwann cells in allografts after Cyclosporin A treatment

Abstract

Keywords

ASJC Scopus subject areas

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