Abstract
The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.
Original language | English (US) |
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Pages (from-to) | 323-329 |
Number of pages | 7 |
Journal | Immunology Today |
Volume | 17 |
Issue number | 7 |
DOIs |
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State | Published - Jul 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology