Susceptibility to type I diabetes: HLA-DQ and DR revisited

Jin Xiong She

Research output: Contribution to journalComment/debatepeer-review

308 Scopus citations


The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.

Original languageEnglish (US)
Pages (from-to)323-329
Number of pages7
JournalImmunology Today
Issue number7
StatePublished - Jul 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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