Abstract
Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.
Original language | English (US) |
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Pages (from-to) | 4409-12 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 18 |
Issue number | 15 |
DOIs | |
State | Published - Aug 1 2008 |
Keywords
- Algorithms
- Animals
- Animals, Inbred Strains
- Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis
- Disease Models, Animal
- Edema/chemically induced
- Foot/pathology
- Mice
- Phospholipases A2/metabolism
- Prostaglandin-Endoperoxide Synthases/metabolism
- Pyrimidines/chemical synthesis
- Rats
- Ulcer/etiology