Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives

Siva S. Panda, Ritu Malik, Mahesh Chand, Subhash C. Jain

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


4-(5-Aryl-4H-[1,2,4]triazol-3-ylmethoxy)-2Hchromen-2-ones have been synthesized by the one pot cyclocondensation reaction of 2-(2-oxo-2H-chromen-4- yloxy)acetohydrazide with aromatic/heterocyclic aldehydes in the presence of ammonium acetate in acetic acid. The structures of all the new compounds have been established on the basis of their analytical and spectral data. These compounds were also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi and some are found to possess significant antimicrobial activity when compared with ciprofloxacin and miconazole.

Original languageEnglish (US)
Pages (from-to)3750-3756
Number of pages7
JournalMedicinal Chemistry Research
Issue number11
StatePublished - Nov 2012
Externally publishedYes


  • 4-Triazolylmethoxy-2H-chromen-2-ones
  • Antimicrobial activity
  • Cyclocondensation
  • Minimum bactericidal concentration
  • Minimum fungicidal concentration

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry


Dive into the research topics of 'Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives'. Together they form a unique fingerprint.

Cite this