Synthesis, in vitro and computational studies of 1,4-disubstituted 1,2,3-triazoles as potential α-glucosidase inhibitors

Keyphrases

• In Vitro Study 100%
• Triazole 100%
• Computational Study 100%
• Glucosidase 100%
• α-glucosidase Inhibitor 100%
• 1,4-disubstituted 1,2,3-triazoles 100%
• Azides 50%
• Cyano 50%
• Nitrophenyl 50%
• Enzyme Function 50%
• Enzyme Inhibition 50%
• Cu-catalyzed 50%
• Enzymatic Assay 50%
• Active Member 50%
• Electron-withdrawing Group 50%
• Cyclohexanol 50%
• Click Reaction 50%
• 1,3-dipoles 50%
• Molecular Docking Studies 50%
• 1H-1,2,3-triazole 50%
• Terminal Alkynes 50%
• Interacting Residues 50%
• Electron-donating 50%
• Protein-ligand Interaction 50%
• Ethynyl 50%

Neuroscience

• In Vitro 100%
• Glucosidase 100%
• Azide 33%
• Protein Interaction 33%
• Cyclohexanol 33%
• Triazole 33%
• Molecular Docking 33%
• Alkyne 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Triazole Derivative 100%
• Glucosidase 100%
• Triazole 25%
• Azide 25%
• Cuprous Ion 25%
• Cyclohexanol 25%
• Protein Ligand 25%
• Alkyne 25%