Synthesis of l-lys-aminoxy-goralatide

Zhiliang Li; Iryna Oleksandrivna Lebedyeva; Deqian Zhao; Lauren Myers; Girinath G. Pillai; Charles Dennis Hall; Alan R. Katritzky

doi:10.1002/psc.2702

Synthesis of l-lys-aminoxy-goralatide

Zhiliang Li, Iryna Oleksandrivna Lebedyeva, Deqian Zhao, Lauren Myers, Girinath G. Pillai, Charles Dennis Hall, Alan R. Katritzky

Chemistry and Physics

Research output: Contribution to journal › Article › peer-review

Abstract

Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.

Original language	English (US)
Pages (from-to)	923-927
Number of pages	5
Journal	Journal of Peptide Science
Volume	20
Issue number	12
DOIs	https://doi.org/10.1002/psc.2702
State	Published - Oct 20 2014

Keywords

Acylation
Coupling
Goralatide
Peptides
Peptidomimetics

ASJC Scopus subject areas

Structural Biology
Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Organic Chemistry

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10.1002/psc.2702

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title = "Synthesis of l-lys-aminoxy-goralatide",

abstract = "Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.",

keywords = "Acylation, Coupling, Goralatide, Peptides, Peptidomimetics",

author = "Zhiliang Li and Lebedyeva, {Iryna Oleksandrivna} and Deqian Zhao and Lauren Myers and Pillai, {Girinath G.} and Hall, {Charles Dennis} and Katritzky, {Alan R.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 European Peptide Society and John Wiley & Sons, Ltd.",

year = "2014",

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day = "20",

doi = "10.1002/psc.2702",

language = "English (US)",

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T1 - Synthesis of l-lys-aminoxy-goralatide

AU - Li, Zhiliang

AU - Lebedyeva, Iryna Oleksandrivna

AU - Zhao, Deqian

AU - Myers, Lauren

AU - Pillai, Girinath G.

AU - Hall, Charles Dennis

AU - Katritzky, Alan R.

PY - 2014/10/20

Y1 - 2014/10/20

N2 - Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.

AB - Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.

KW - Acylation

KW - Coupling

KW - Goralatide

KW - Peptides

KW - Peptidomimetics

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DO - 10.1002/psc.2702

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JO - Journal of Peptide Science

JF - Journal of Peptide Science

IS - 12

ER -

Synthesis of l-lys-aminoxy-goralatide

Abstract

Keywords

ASJC Scopus subject areas

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