Taurine-containing water-soluble peptidomimetics were designed and synthesized. N-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. N-protection of taurine with Cbz and SO 2-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-conjugates and sulfonopeptides.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Organic Chemistry|
|State||Published - Mar 21 2014|
ASJC Scopus subject areas
- Organic Chemistry