The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus

Neil L. Harrison; David M. Lovinger; Nevin A. Lambert; Timothy J. Teyler; Rolf Prager; Jennifer Ong; David I.B. Kerr

doi:10.1016/0304-3940(90)90851-Y

The actions of 2-hydroxy-saclofen at presynaptic GABA_B receptors in the rat hippocampus

Neil L. Harrison, David M. Lovinger, Nevin A. Lambert, Timothy J. Teyler, Rolf Prager, Jennifer Ong, David I.B. Kerr

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABA_B receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABA_B receptors on excitatory terminals in the hippocampus.

Original language	English (US)
Pages (from-to)	272-276
Number of pages	5
Journal	Neuroscience Letters
Volume	119
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(90)90851-Y
State	Published - Nov 13 1990
Externally published	Yes

Keywords

2-Hydroxysaclofen
GABA receptor
Hippocampus
Rat

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0304-3940(90)90851-Y

Cite this

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title = "The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus",

abstract = "The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.",

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T1 - The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus

AU - Harrison, Neil L.

AU - Lovinger, David M.

AU - Lambert, Nevin A.

AU - Teyler, Timothy J.

AU - Prager, Rolf

AU - Ong, Jennifer

AU - Kerr, David I.B.

PY - 1990/11/13

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AB - The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.

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