The amelioration of mercury-induced embryotoxic effects by simultaneous treatment with zinc

Thomas F. Gale

doi:10.1016/0013-9351(84)90147-6

The amelioration of mercury-induced embryotoxic effects by simultaneous treatment with zinc

Thomas F. Gale

Cellular Biology and Anatomy

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Prior work has demonstrated that inorganic mercury produces a number of toxic effects in embryos when this metal is administered to pregnant hamsters subcutaneously on the eighth gestation day. Also, treatment of various pregnant animals with zinc produces little evidence of embryotoxicity. The literature reveals that the simultaneous exposure of pregnant animals to different combinations of teratogenic and nonteratogenic agents produces variable responses which can be characterized as either protective or synergistic types of interactions. The purpose of this study was to determine the effect of subcutaneously injected combinations of zinc and mercury on the developing hamster embryo. The major conclusion drawn from this work is that the simultaneous maternal treatment with zinc and mercury ameliorates the harmful effects produced by treatment with mercury alone.

Original language	English (US)
Pages (from-to)	405-412
Number of pages	8
Journal	Environmental Research
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/0013-9351(84)90147-6
State	Published - Dec 1984

ASJC Scopus subject areas

Biochemistry
Environmental Science(all)

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10.1016/0013-9351(84)90147-6

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title = "The amelioration of mercury-induced embryotoxic effects by simultaneous treatment with zinc",

abstract = "Prior work has demonstrated that inorganic mercury produces a number of toxic effects in embryos when this metal is administered to pregnant hamsters subcutaneously on the eighth gestation day. Also, treatment of various pregnant animals with zinc produces little evidence of embryotoxicity. The literature reveals that the simultaneous exposure of pregnant animals to different combinations of teratogenic and nonteratogenic agents produces variable responses which can be characterized as either protective or synergistic types of interactions. The purpose of this study was to determine the effect of subcutaneously injected combinations of zinc and mercury on the developing hamster embryo. The major conclusion drawn from this work is that the simultaneous maternal treatment with zinc and mercury ameliorates the harmful effects produced by treatment with mercury alone.",

author = "Gale, {Thomas F.}",

note = "Funding Information: This study was supported by a grant from the American Heart Association, Georgia Affiliate. The typing assistance of Ms. Linda Baez and Ms. Connie Benson are greatly appreciated.",

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N2 - Prior work has demonstrated that inorganic mercury produces a number of toxic effects in embryos when this metal is administered to pregnant hamsters subcutaneously on the eighth gestation day. Also, treatment of various pregnant animals with zinc produces little evidence of embryotoxicity. The literature reveals that the simultaneous exposure of pregnant animals to different combinations of teratogenic and nonteratogenic agents produces variable responses which can be characterized as either protective or synergistic types of interactions. The purpose of this study was to determine the effect of subcutaneously injected combinations of zinc and mercury on the developing hamster embryo. The major conclusion drawn from this work is that the simultaneous maternal treatment with zinc and mercury ameliorates the harmful effects produced by treatment with mercury alone.

AB - Prior work has demonstrated that inorganic mercury produces a number of toxic effects in embryos when this metal is administered to pregnant hamsters subcutaneously on the eighth gestation day. Also, treatment of various pregnant animals with zinc produces little evidence of embryotoxicity. The literature reveals that the simultaneous exposure of pregnant animals to different combinations of teratogenic and nonteratogenic agents produces variable responses which can be characterized as either protective or synergistic types of interactions. The purpose of this study was to determine the effect of subcutaneously injected combinations of zinc and mercury on the developing hamster embryo. The major conclusion drawn from this work is that the simultaneous maternal treatment with zinc and mercury ameliorates the harmful effects produced by treatment with mercury alone.

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The amelioration of mercury-induced embryotoxic effects by simultaneous treatment with zinc

Abstract

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