The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart

Jinbao Liu; Huabo Su; Xuejun Wang

doi:10.1080/15548627.2015.1136773

The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart

Jinbao Liu, Huabo Su, Xuejun Wang

Pharmacology and Toxicology

Research output: Contribution to journal › Comment/debate › peer-review

7 Scopus citations

Abstract

ABSTRACT: We demonstrated for the first time that the COP9 signalosome (COPS) controls the degradation of a surrogate and a bona fide misfolded protein in the cytosol of cardiomyocytes likely via supporting ubiquitination by CUL/cullin-RING ligases, and that Cops8 hypomorphism exacerbates cardiac proteinopathy in mice, in which autophagic impairment appears to be in play. It will be extremely imprtant to investigate cardiac ablation of another Cops gene to decipher whether COPS8 deficiency phenotypes are attributable to the COPS or unique to COPS8.

Original language	English (US)
Pages (from-to)	601-602
Number of pages	2
Journal	Autophagy
Volume	12
Issue number	3
DOIs	https://doi.org/10.1080/15548627.2015.1136773
State	Published - 2016

Keywords

COP9 signalosome
autophagy
cullin-RING ligase
desmin-related cardiomyopathy
protein quality control

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1080/15548627.2015.1136773

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title = "The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart",

abstract = "ABSTRACT: We demonstrated for the first time that the COP9 signalosome (COPS) controls the degradation of a surrogate and a bona fide misfolded protein in the cytosol of cardiomyocytes likely via supporting ubiquitination by CUL/cullin-RING ligases, and that Cops8 hypomorphism exacerbates cardiac proteinopathy in mice, in which autophagic impairment appears to be in play. It will be extremely imprtant to investigate cardiac ablation of another Cops gene to decipher whether COPS8 deficiency phenotypes are attributable to the COPS or unique to COPS8.",

keywords = "COP9 signalosome, autophagy, cullin-RING ligase, desmin-related cardiomyopathy, protein quality control",

author = "Jinbao Liu and Huabo Su and Xuejun Wang",

note = "Funding Information: This work is in part supported by NIH grants R01HL085629, R01HL072166 (to X.W.) and R01HL124248 (to H.S.) and by the National High Technology Research and Development Program of China 2006AA02Z4B5 (to J.L) Publisher Copyright: {\textcopyright} 2016 Taylor & Francis.",

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journal = "Autophagy",

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T1 - The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart

AU - Liu, Jinbao

AU - Su, Huabo

AU - Wang, Xuejun

N1 - Funding Information: This work is in part supported by NIH grants R01HL085629, R01HL072166 (to X.W.) and R01HL124248 (to H.S.) and by the National High Technology Research and Development Program of China 2006AA02Z4B5 (to J.L) Publisher Copyright: © 2016 Taylor & Francis.

PY - 2016

Y1 - 2016

N2 - ABSTRACT: We demonstrated for the first time that the COP9 signalosome (COPS) controls the degradation of a surrogate and a bona fide misfolded protein in the cytosol of cardiomyocytes likely via supporting ubiquitination by CUL/cullin-RING ligases, and that Cops8 hypomorphism exacerbates cardiac proteinopathy in mice, in which autophagic impairment appears to be in play. It will be extremely imprtant to investigate cardiac ablation of another Cops gene to decipher whether COPS8 deficiency phenotypes are attributable to the COPS or unique to COPS8.

AB - ABSTRACT: We demonstrated for the first time that the COP9 signalosome (COPS) controls the degradation of a surrogate and a bona fide misfolded protein in the cytosol of cardiomyocytes likely via supporting ubiquitination by CUL/cullin-RING ligases, and that Cops8 hypomorphism exacerbates cardiac proteinopathy in mice, in which autophagic impairment appears to be in play. It will be extremely imprtant to investigate cardiac ablation of another Cops gene to decipher whether COPS8 deficiency phenotypes are attributable to the COPS or unique to COPS8.

KW - COP9 signalosome

KW - autophagy

KW - cullin-RING ligase

KW - desmin-related cardiomyopathy

KW - protein quality control

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JO - Autophagy

JF - Autophagy

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The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart

Abstract

Keywords

ASJC Scopus subject areas

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