The effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages

Warren B. Karp; Thomas F. Gale; S. B. Subramanyam; Robert H. DuRant

doi:10.1016/0013-9351(85)90030-1

The effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages

Warren B. Karp, Thomas F. Gale, S. B. Subramanyam, Robert H. DuRant

Cellular Biology and Anatomy

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study establishes levels of activity of glucose-6-phosphate dehydrogenase (G6PD), glycogen phosphorylase (GP), and cytochrome c oxidase (cyt c ox) in maternal, placental, and fetal tissues at Days 9, 12, and 15 in the 16-day gestation period of the hamster, and following a single dose of either 8 or 15 mg/kg mercuric acetate on the eighth gestational day. Mercury significantly elevated maternal kidney G6PD activity and decreased GP activity. The increase in kidney G6PD strongly correlated with observed urine and kidney abnormalities.

Original language	English (US)
Pages (from-to)	351-358
Number of pages	8
Journal	Environmental Research
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/0013-9351(85)90030-1
State	Published - Apr 1985

ASJC Scopus subject areas

Biochemistry
Environmental Science(all)

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10.1016/0013-9351(85)90030-1

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title = "The effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages",

abstract = "This study establishes levels of activity of glucose-6-phosphate dehydrogenase (G6PD), glycogen phosphorylase (GP), and cytochrome c oxidase (cyt c ox) in maternal, placental, and fetal tissues at Days 9, 12, and 15 in the 16-day gestation period of the hamster, and following a single dose of either 8 or 15 mg/kg mercuric acetate on the eighth gestational day. Mercury significantly elevated maternal kidney G6PD activity and decreased GP activity. The increase in kidney G6PD strongly correlated with observed urine and kidney abnormalities.",

author = "Karp, {Warren B.} and Gale, {Thomas F.} and Subramanyam, {S. B.} and DuRant, {Robert H.}",

note = "Funding Information: We thank Ms. Peggy King for her help in preparing the manuscript for publication. This study was supported in part by a grant from the American Heart Association. Georgia Affiliate, and the Department of Pediatrics, Medical College of Georgia.",

year = "1985",

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T1 - The effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages

AU - Karp, Warren B.

AU - Gale, Thomas F.

AU - Subramanyam, S. B.

AU - DuRant, Robert H.

N1 - Funding Information: We thank Ms. Peggy King for her help in preparing the manuscript for publication. This study was supported in part by a grant from the American Heart Association. Georgia Affiliate, and the Department of Pediatrics, Medical College of Georgia.

PY - 1985/4

Y1 - 1985/4

N2 - This study establishes levels of activity of glucose-6-phosphate dehydrogenase (G6PD), glycogen phosphorylase (GP), and cytochrome c oxidase (cyt c ox) in maternal, placental, and fetal tissues at Days 9, 12, and 15 in the 16-day gestation period of the hamster, and following a single dose of either 8 or 15 mg/kg mercuric acetate on the eighth gestational day. Mercury significantly elevated maternal kidney G6PD activity and decreased GP activity. The increase in kidney G6PD strongly correlated with observed urine and kidney abnormalities.

AB - This study establishes levels of activity of glucose-6-phosphate dehydrogenase (G6PD), glycogen phosphorylase (GP), and cytochrome c oxidase (cyt c ox) in maternal, placental, and fetal tissues at Days 9, 12, and 15 in the 16-day gestation period of the hamster, and following a single dose of either 8 or 15 mg/kg mercuric acetate on the eighth gestational day. Mercury significantly elevated maternal kidney G6PD activity and decreased GP activity. The increase in kidney G6PD strongly correlated with observed urine and kidney abnormalities.

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The effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages

Abstract

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