The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned

William V. McCall; Kayla Mercado; Tess N. Dzurny; Laryssa L. McCloud; Andrew D. Krystal; Ruth M. Benca; Peter B. Rosenquist; Stephen W. Looney

doi:10.1016/j.psychres.2023.115576

The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned

William V. McCall, Kayla Mercado, Tess N. Dzurny, Laryssa L. McCloud, Andrew D. Krystal, Ruth M. Benca, Peter B. Rosenquist, Stephen W. Looney

Psychiatry and Health Behavior

Research output: Contribution to journal › Article › peer-review

Abstract

The REST-IT study found the addition of zolpidem-controlled release (CR) provided a significant reduction in observer-rated measurement of suicidal ideation (the Columbia Suicide Severity Rating Scale) in 103 depressed outpatients with insomnia and suicidal ideation, but without significant change in a self-report measure of suicidal ideation (the Scale for Suicide Ideation). This secondary analysis of the REST-IT data examined the suicide item of another observer-rated scale, the Hamilton Rating Scale for Depression (HRSD), further clarifying the impact of insomnia-focused treatment on suicidal ideation. This analysis established a significant advantage for zolpidem-CR compared with placebo on the HRSD suicide item.

Original language	English (US)
Article number	115576
Journal	Psychiatry Research
Volume	330
DOIs	https://doi.org/10.1016/j.psychres.2023.115576
State	Published - Dec 2023

Keywords

Hypnotic
Observer-rated
Self-report

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2023.115576

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McCall, W. V., Mercado, K., Dzurny, T. N., McCloud, L. L., Krystal, A. D., Benca, R. M., Rosenquist, P. B., & Looney, S. W. (2023). The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned. Psychiatry Research, 330, Article 115576. https://doi.org/10.1016/j.psychres.2023.115576

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abstract = "The REST-IT study found the addition of zolpidem-controlled release (CR) provided a significant reduction in observer-rated measurement of suicidal ideation (the Columbia Suicide Severity Rating Scale) in 103 depressed outpatients with insomnia and suicidal ideation, but without significant change in a self-report measure of suicidal ideation (the Scale for Suicide Ideation). This secondary analysis of the REST-IT data examined the suicide item of another observer-rated scale, the Hamilton Rating Scale for Depression (HRSD), further clarifying the impact of insomnia-focused treatment on suicidal ideation. This analysis established a significant advantage for zolpidem-CR compared with placebo on the HRSD suicide item.",

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AU - Dzurny, Tess N.

AU - McCloud, Laryssa L.

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AU - Benca, Ruth M.

AU - Rosenquist, Peter B.

AU - Looney, Stephen W.

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The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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