The Environmental Determinants of Diabetes in the Young (TEDDY) study: Study design

Jeffrey Krischer, Marian Rewers, Katherine Barriga, Judith Baxter, Ann Deas, George Eisenbarth, Lisa Emery, Patricia Gesualdo, Michelle Hoffman, Jill Norris, Kathleen Waugh, Stacey Weber, Jin-Xiong She, Andy Muir, Desmond Schatz, Diane Hopkins, Leigh Steed, Katherine Silvis, Meena Shankar, Y. Hua huangPing Yang, Wei Peng Zheng, Hong Jie Wang, Kim English, Richard A McIndoe, Anette G. Ziegler, Ezio Bonifacio, Andrea Baumgarten, Sandra Hummel, Mathilde Kersting, Stephanie Koenig, Annette Knopff, Angelika Locher, Roswith Roth, Stefanie Schoen, Petra Schwaiger, Wolfgang Sichert-Hellert, Christiane Winkler, Diana Zimmermann, Olli G. Simell, Kirsti Nanto-Salonen, Jorma Ilonen, Mikael Knip, Riitta Veijola, Tuula Simell, Ulla Uusitalo, Heikki Hyöty, Suvi M. Virtanen, Carina Kronberg-Kippila̧, Maija Torma, Eeva Ruohonen, Minna Romo, Elina Mantymaki, Tiina Niininen, Mia Nyblom, Aino Stenius, Åke Lernmark, Peter Almgren, Carin Andrén-Aronsson, Eva Andersson, Sylvia Bianconi-Svensson, Ulla Marie Carlsson, Corrado Cilio, Joanna Gerardsson, Barbro Gustavsson, Anna Hansson, Gertie Hansson, Ida Hansson, Sten Ivarsson, Helena Larsson, Elli Karlsson, Anastasia Katsarou, Barbro Lernmark, Thea Massadakis, Anita Nilsson, Monica Sedig Järvirova, Birgitta Sjöberg, Anne Wallin, Åsa Wimar, William A. Hagopian, Michael Brantley, Claire Cowen, Peng Hui, Kristen M. Hay, Melissa Jackson, Viktoria Stepikova, Jennifer Ugale, Jeffrey P. Krischer, Carole Bray, David Cuthbertson, Veena Gowda, Kimberly Hunt, Shu Liu, Jamie Malloy, Cristina McCarthy, Wendy McLeod, Susan Moyers, Lavanya Nallamshetty, Susan Smith, Beena Akolkar, Thomas Briese, Henry Erlich, Suzanne Bennett Johnson, Steve Oberste

Research output: Contribution to journalArticlepeer-review

228 Scopus citations


The primary objective of this multicenter, multinational, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression or with protection from the development of T1DM will also be identified. The Environmental Determinants of Diabetes in the Young (TEDDY) is an observational cohort study in which newborns who are younger than 4 months and have high-risk human leukocyte antigen alleles in the general population or are first-degree relatives (FDRs) of patients affected with T1DM will be enrolled. Six clinical centers in the USA and Europe will screen 361 588 newborns, of which it is anticipated that 17 804 will be eligible for enrollment with just over 7800 followed. Recruitment will occur over 5 yr, with children being followed to the age of 15 yr. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay, or reverse T1DM.

Original languageEnglish (US)
Pages (from-to)286-298
Number of pages13
JournalPediatric Diabetes
Issue number5
StatePublished - Oct 2007


  • Dietary factors
  • Environmental triggers
  • Epidemiological study
  • HLA
  • Infectious agents factors islet autoimmunity
  • Psychosocial factors
  • T1DM

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'The Environmental Determinants of Diabetes in the Young (TEDDY) study: Study design'. Together they form a unique fingerprint.

Cite this