The hemodynamic response to chronic hyperinsulinemia in conscious dogs

Michael W. Brands; H. Leland Mizelle; Carlo A. Gaillard; Drew A. Hildebrandt; John E. Hall

doi:10.1093/ajh/4.2.164

The hemodynamic response to chronic hyperinsulinemia in conscious dogs

Michael W. Brands, H. Leland Mizelle, Carlo A. Gaillard, Drew A. Hildebrandt, John E. Hall

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glucose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately sixfold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean arterial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8% above control by day 7. Total peripheral resistance decreased to 69 ± 5% of control. Urinary sodium excretion was significantly decreased and was accom panied by a 22% increase in extracellular fluid volume with no change in blood volume. All parameters returned to control levels during the recovery period. These data suggest that, in addition to promoting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect.

Original language	English (US)
Pages (from-to)	164-168
Number of pages	5
Journal	American journal of hypertension
Volume	4
Issue number	2
DOIs	https://doi.org/10.1093/ajh/4.2.164
State	Published - Nov 1991
Externally published	Yes

Keywords

Blood volume
Cardiac output
Hypertension
Insulin
Sodium excretion

ASJC Scopus subject areas

Internal Medicine

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10.1093/ajh/4.2.164

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title = "The hemodynamic response to chronic hyperinsulinemia in conscious dogs",

abstract = "This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glucose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately sixfold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean arterial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8% above control by day 7. Total peripheral resistance decreased to 69 ± 5% of control. Urinary sodium excretion was significantly decreased and was accom panied by a 22% increase in extracellular fluid volume with no change in blood volume. All parameters returned to control levels during the recovery period. These data suggest that, in addition to promoting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect.",

keywords = "Blood volume, Cardiac output, Hypertension, Insulin, Sodium excretion",

author = "Brands, {Michael W.} and {Leland Mizelle}, H. and Gaillard, {Carlo A.} and Hildebrandt, {Drew A.} and Hall, {John E.}",

note = "Funding Information: This work was supported by National Institutes of Health grants HL39399, HL11678, and HL23502, and by the Netherlands Organization for Scientific Research. Drs. Brands and Hildebrandt are recipients of National Institutes of Health Individual National Research Service Awards HL08171 and HL07931.",

year = "1991",

month = nov,

doi = "10.1093/ajh/4.2.164",

language = "English (US)",

volume = "4",

pages = "164--168",

journal = "American journal of hypertension",

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AU - Brands, Michael W.

AU - Leland Mizelle, H.

AU - Gaillard, Carlo A.

AU - Hildebrandt, Drew A.

AU - Hall, John E.

N1 - Funding Information: This work was supported by National Institutes of Health grants HL39399, HL11678, and HL23502, and by the Netherlands Organization for Scientific Research. Drs. Brands and Hildebrandt are recipients of National Institutes of Health Individual National Research Service Awards HL08171 and HL07931.

PY - 1991/11

Y1 - 1991/11

N2 - This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glucose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately sixfold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean arterial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8% above control by day 7. Total peripheral resistance decreased to 69 ± 5% of control. Urinary sodium excretion was significantly decreased and was accom panied by a 22% increase in extracellular fluid volume with no change in blood volume. All parameters returned to control levels during the recovery period. These data suggest that, in addition to promoting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect.

AB - This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glucose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately sixfold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean arterial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8% above control by day 7. Total peripheral resistance decreased to 69 ± 5% of control. Urinary sodium excretion was significantly decreased and was accom panied by a 22% increase in extracellular fluid volume with no change in blood volume. All parameters returned to control levels during the recovery period. These data suggest that, in addition to promoting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect.

KW - Blood volume

KW - Cardiac output

KW - Hypertension

KW - Insulin

KW - Sodium excretion

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The hemodynamic response to chronic hyperinsulinemia in conscious dogs

Abstract

Keywords

ASJC Scopus subject areas

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