The hemodynamic response to chronic hyperinsulinemia in conscious dogs

Michael W. Brands, H. Leland Mizelle, Carlo A. Gaillard, Drew A. Hildebrandt, John E. Hall

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glu­cose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately six­fold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean ar­terial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8% above control by day 7. Total peripheral resistance decreased to 69 ± 5% of control. Urinary sodium ex­cretion was significantly decreased and was accom­ panied by a 22% increase in extracellular fluid vol­ume with no change in blood volume. All parame­ters returned to control levels during the recovery period. These data suggest that, in addition to pro­moting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect.

Original languageEnglish (US)
Pages (from-to)164-168
Number of pages5
JournalAmerican journal of hypertension
Issue number2
StatePublished - Nov 1991
Externally publishedYes


  • Blood volume
  • Cardiac output
  • Hypertension
  • Insulin
  • Sodium excretion

ASJC Scopus subject areas

  • Internal Medicine


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