TY - JOUR
T1 - The impact of race on metabolic, graft, and patient outcomes after pancreas transplantation
AU - Gonzales, Haley M.
AU - Taber, David J.
AU - Nadig, Satish
AU - Patel, Neha
AU - Lin, Angello
AU - Baliga, Prabhakar K.
AU - Rohan, Vinayak S.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/4
Y1 - 2022/4
N2 - Background: Racial disparities following pancreas transplantation (PTX) are poorly defined. Methods: This was a large-scale, single-center, longitudinal cohort study including adult PTX recipients. Patients were grouped by race to allow for comparisons. Results: 287 PTX recipients were included; 125 (43.5%) were African American (AA). At baseline, AAs had a significantly higher proportion of T2DM (19.4% vs. 5.7%, p = 0.001), were younger, and more likely to be female. AAs experienced significantly higher rates of pancreatic leaks and post-operative bleeding. PTX rejection was comparable, however, kidney rejection tended to be higher among AA SPKs. Long-term mean HgbA1C levels were significantly higher among AAs (6.9% vs. 6.3%, p = 0.039). Patient and graft survival was comparable between groups, but early patient survival tended to be lower in AAs. Conclusions: This study demonstrated significant perioperative health disparities among AA PTX recipients, including poorer glycemic control and more early deaths, despite similar long-term patient and graft survival.
AB - Background: Racial disparities following pancreas transplantation (PTX) are poorly defined. Methods: This was a large-scale, single-center, longitudinal cohort study including adult PTX recipients. Patients were grouped by race to allow for comparisons. Results: 287 PTX recipients were included; 125 (43.5%) were African American (AA). At baseline, AAs had a significantly higher proportion of T2DM (19.4% vs. 5.7%, p = 0.001), were younger, and more likely to be female. AAs experienced significantly higher rates of pancreatic leaks and post-operative bleeding. PTX rejection was comparable, however, kidney rejection tended to be higher among AA SPKs. Long-term mean HgbA1C levels were significantly higher among AAs (6.9% vs. 6.3%, p = 0.039). Patient and graft survival was comparable between groups, but early patient survival tended to be lower in AAs. Conclusions: This study demonstrated significant perioperative health disparities among AA PTX recipients, including poorer glycemic control and more early deaths, despite similar long-term patient and graft survival.
KW - African americans
KW - Diabetes mellitus
KW - Graft survival
KW - Healthcare disparities
KW - Pancreas transplantation
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U2 - 10.1016/j.amjsurg.2021.06.005
DO - 10.1016/j.amjsurg.2021.06.005
M3 - Article
C2 - 34158161
AN - SCOPUS:85108292357
SN - 0002-9610
VL - 223
SP - 812
EP - 816
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 4
ER -
