The implications of histamine metabolism and signaling in renal function

Anastasia V. Sudarikova, Mikhail V. Fomin, Irina A. Yankelevich, Daria V. Ilatovskaya

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Inflammation is an essential part of the immune response; it has been found to be central to the disruption of kidney function in acute kidney injury, diabetic nephropathy, hypertension, and other renal conditions. One of the well-known mediators of the inflammatory response is histamine. Histamine receptors are expressed throughout different tissues, including the kidney, and their inhibition has proven to be a viable strategy for the treatment of many inflammation-associated diseases. Here, we provide an overview of the current knowledge regarding the role of histamine and its metabolism in the kidney. Establishing the importance of histamine signaling for kidney function will enable new approaches for the treatment of kidney diseases associated with inflammation.

Original languageEnglish (US)
Article numbere14845
JournalPhysiological reports
Issue number8
StatePublished - Apr 2021

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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