TY - JOUR
T1 - The implications of histamine metabolism and signaling in renal function
AU - Sudarikova, Anastasia V.
AU - Fomin, Mikhail V.
AU - Yankelevich, Irina A.
AU - Ilatovskaya, Daria V.
N1 - Funding Information:
This work was supported by NHLBI R01HL148115, the APS Lazaro J Mandel award (to DVI), and the RFBR 19‐015‐00211 (to AVS).
Publisher Copyright:
© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society
PY - 2021/4
Y1 - 2021/4
N2 - Inflammation is an essential part of the immune response; it has been found to be central to the disruption of kidney function in acute kidney injury, diabetic nephropathy, hypertension, and other renal conditions. One of the well-known mediators of the inflammatory response is histamine. Histamine receptors are expressed throughout different tissues, including the kidney, and their inhibition has proven to be a viable strategy for the treatment of many inflammation-associated diseases. Here, we provide an overview of the current knowledge regarding the role of histamine and its metabolism in the kidney. Establishing the importance of histamine signaling for kidney function will enable new approaches for the treatment of kidney diseases associated with inflammation.
AB - Inflammation is an essential part of the immune response; it has been found to be central to the disruption of kidney function in acute kidney injury, diabetic nephropathy, hypertension, and other renal conditions. One of the well-known mediators of the inflammatory response is histamine. Histamine receptors are expressed throughout different tissues, including the kidney, and their inhibition has proven to be a viable strategy for the treatment of many inflammation-associated diseases. Here, we provide an overview of the current knowledge regarding the role of histamine and its metabolism in the kidney. Establishing the importance of histamine signaling for kidney function will enable new approaches for the treatment of kidney diseases associated with inflammation.
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U2 - 10.14814/phy2.14845
DO - 10.14814/phy2.14845
M3 - Review article
C2 - 33932106
AN - SCOPUS:85105395799
SN - 2051-817X
VL - 9
JO - Physiological reports
JF - Physiological reports
IS - 8
M1 - e14845
ER -
