TY - JOUR
T1 - The metric properties of a novel non-motor symptoms scale for Parkinson's disease
T2 - Results from an international pilot study
AU - Chaudhuri, Kallol Ray
AU - Martinez-Martin, Pablo
AU - Brown, Richard G.
AU - Sethi, Kapil
AU - Stocchi, Fabrizio
AU - Odin, Per
AU - Ondo, William
AU - Abe, Kazuo
AU - MacPhee, Graeme
AU - MacMahon, Doug
AU - Barone, Paolo
AU - Rabey, Martin
AU - Forbes, Alison
AU - Breen, Kieran
AU - Tluk, Susanne
AU - Naidu, Yogini
AU - Olanow, Warren
AU - Williams, Adrian J.
AU - Thomas, Sue
AU - Rye, David
AU - Tsuboi, Yoshio
AU - Hand, Annette
AU - Schapira, Anthony H.V.
PY - 2007/10/15
Y1 - 2007/10/15
N2 - Non-motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce quality of life and at present there is no validated clinical tool to assess the progress or potential response to treatment of NMS. A new 30-item scale for the assessment of NMS in PD (NMSS) was developed. NMSS contains nine dimensions: cardiovascular, sleep/fatigue, mood/cognition, perceptual problems, attention/memory, gastrointestinal, urinary, sexual function, and miscellany. The metric attributes of this instrument were analyzed. Data from 242 patients mean age 67.2 ± 11 years, duration of disease 6.4 ± 6 years, and 57.3% male across all stages of PD were collected from the centers in Europe, USA, and Japan. The mean NMSS score was 56.5 ± 40.7, (range: 0-243) and only one declared no NMS. The scale provided 99.2% complete data for the analysis with the total score being free of floor and ceiling effect. Satisfactory scaling assumptions (multitrait scaling success rate >95% for all domains except miscellany) and internal consistency were reported for most of the domains (mean α, 0.61). Factor analysis supported the a prori nine domain structure (63% of the variance) while a small test-retest study showed satisfactory reproducibility (ICC > 0.80) for all domains except cardiovascular (ICC = 0.45). In terms of validity, the scale showed modest association with indicators of motor symptom severity and disease progression but a high correlation with other measures of NMS (NMSQuest) and health-related quality of life measure (PDQ-8) (both, rS = 0.70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire.
AB - Non-motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce quality of life and at present there is no validated clinical tool to assess the progress or potential response to treatment of NMS. A new 30-item scale for the assessment of NMS in PD (NMSS) was developed. NMSS contains nine dimensions: cardiovascular, sleep/fatigue, mood/cognition, perceptual problems, attention/memory, gastrointestinal, urinary, sexual function, and miscellany. The metric attributes of this instrument were analyzed. Data from 242 patients mean age 67.2 ± 11 years, duration of disease 6.4 ± 6 years, and 57.3% male across all stages of PD were collected from the centers in Europe, USA, and Japan. The mean NMSS score was 56.5 ± 40.7, (range: 0-243) and only one declared no NMS. The scale provided 99.2% complete data for the analysis with the total score being free of floor and ceiling effect. Satisfactory scaling assumptions (multitrait scaling success rate >95% for all domains except miscellany) and internal consistency were reported for most of the domains (mean α, 0.61). Factor analysis supported the a prori nine domain structure (63% of the variance) while a small test-retest study showed satisfactory reproducibility (ICC > 0.80) for all domains except cardiovascular (ICC = 0.45). In terms of validity, the scale showed modest association with indicators of motor symptom severity and disease progression but a high correlation with other measures of NMS (NMSQuest) and health-related quality of life measure (PDQ-8) (both, rS = 0.70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire.
KW - Non-motor
KW - PD
KW - Quality of life
KW - Questionnaire
KW - UPDRS
UR - http://www.scopus.com/inward/record.url?scp=36248998208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36248998208&partnerID=8YFLogxK
U2 - 10.1002/mds.21596
DO - 10.1002/mds.21596
M3 - Article
C2 - 17674410
AN - SCOPUS:36248998208
SN - 0885-3185
VL - 22
SP - 1901
EP - 1911
JO - Movement Disorders
JF - Movement Disorders
IS - 13
ER -