The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury

Physics & Astronomy

• atrophy 100%
• liver 66%
• drugs 60%
• fusion 48%
• proteins 47%
• optics 43%
• knockout mice 8%
• homeostasis 6%
• mitochondria 5%
• metabolism 5%
• respiration 5%
• toxicity 5%
• causes 5%
• mice 4%
• permeability 3%
• assembly 3%

Medicine & Life Sciences

• Autosomal Dominant Optic Atrophy 96%
• Chemical and Drug Induced Liver Injury 78%
• Mitochondrial Dynamics 77%
• Mitochondrial Proteins 68%
• Liver 31%
• Liver Diseases 8%
• oligomycin sensitivity-conferring protein 8%
• Mitochondrial Transmembrane Permeability-Driven Necrosis 7%
• Drug-Related Side Effects and Adverse Reactions 4%
• Knockout Mice 4%
• Respiration 4%
• Mitochondria 4%
• Poisons 3%
• Homeostasis 3%
• Wounds and Injuries 2%
• Pharmaceutical Preparations 2%

Chemical Compounds

• Drug 31%
• Protein 24%
• Metabolic 24%
• Permeability 23%
• Pharmacological Metabolism 23%
• Toxic 22%
• Resistance 18%