The phosphoprotein Op18/stathmin is differentially expressed in ovarian cancer

Douglas K. Price; Jennifer R. Ball; Zahra Bahrani-Mostafavi; Judith C. Vachris; Jay S. Kaufman; R. Wendel Naumann; Robert V. Higgins; James B. Hall

doi:10.3109/07357900009012204

The phosphoprotein Op18/stathmin is differentially expressed in ovarian cancer

Douglas K. Price, Jennifer R. Ball, Zahra Bahrani-Mostafavi, Judith C. Vachris, Jay S. Kaufman, R. Wendel Naumann, Robert V. Higgins, James B. Hall

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

To identify potential prognostic indicators of ovarian cancer and identify targets for therapeutic strategies, mRNA differential display was used to analyze gene expression differences in normal, benign, and cancerous ovarian tissue. One cDNA isolated by this technique, Op18/stathmin, is a highly conserved gene that is reported to have many different functions within a cell, including signal transduction, control of the cell cycle, and the regulation of microtubules. Quantitative Northern blot analysis of 12 malignant ovarian samples, 8 benign ovarian tumors, and 10 normal ovarian tissue samples demonstrated overexpression of Op18/stathmin mRNA in the malignant cancers. Immunohistochemistry showed an apparent overexpression of Op18/stathmin protein level and an association with proliferating cells.

Original language	English (US)
Pages (from-to)	722-730
Number of pages	9
Journal	Cancer Investigation
Volume	18
Issue number	8
DOIs	https://doi.org/10.3109/07357900009012204
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/07357900009012204

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title = "The phosphoprotein Op18/stathmin is differentially expressed in ovarian cancer",

abstract = "To identify potential prognostic indicators of ovarian cancer and identify targets for therapeutic strategies, mRNA differential display was used to analyze gene expression differences in normal, benign, and cancerous ovarian tissue. One cDNA isolated by this technique, Op18/stathmin, is a highly conserved gene that is reported to have many different functions within a cell, including signal transduction, control of the cell cycle, and the regulation of microtubules. Quantitative Northern blot analysis of 12 malignant ovarian samples, 8 benign ovarian tumors, and 10 normal ovarian tissue samples demonstrated overexpression of Op18/stathmin mRNA in the malignant cancers. Immunohistochemistry showed an apparent overexpression of Op18/stathmin protein level and an association with proliferating cells.",

author = "Price, {Douglas K.} and Ball, {Jennifer R.} and Zahra Bahrani-Mostafavi and Vachris, {Judith C.} and Kaufman, {Jay S.} and Naumann, {R. Wendel} and Higgins, {Robert V.} and Hall, {James B.}",

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doi = "10.3109/07357900009012204",

language = "English (US)",

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T1 - The phosphoprotein Op18/stathmin is differentially expressed in ovarian cancer

AU - Price, Douglas K.

AU - Ball, Jennifer R.

AU - Bahrani-Mostafavi, Zahra

AU - Vachris, Judith C.

AU - Kaufman, Jay S.

AU - Naumann, R. Wendel

AU - Higgins, Robert V.

AU - Hall, James B.

PY - 2000

Y1 - 2000

N2 - To identify potential prognostic indicators of ovarian cancer and identify targets for therapeutic strategies, mRNA differential display was used to analyze gene expression differences in normal, benign, and cancerous ovarian tissue. One cDNA isolated by this technique, Op18/stathmin, is a highly conserved gene that is reported to have many different functions within a cell, including signal transduction, control of the cell cycle, and the regulation of microtubules. Quantitative Northern blot analysis of 12 malignant ovarian samples, 8 benign ovarian tumors, and 10 normal ovarian tissue samples demonstrated overexpression of Op18/stathmin mRNA in the malignant cancers. Immunohistochemistry showed an apparent overexpression of Op18/stathmin protein level and an association with proliferating cells.

AB - To identify potential prognostic indicators of ovarian cancer and identify targets for therapeutic strategies, mRNA differential display was used to analyze gene expression differences in normal, benign, and cancerous ovarian tissue. One cDNA isolated by this technique, Op18/stathmin, is a highly conserved gene that is reported to have many different functions within a cell, including signal transduction, control of the cell cycle, and the regulation of microtubules. Quantitative Northern blot analysis of 12 malignant ovarian samples, 8 benign ovarian tumors, and 10 normal ovarian tissue samples demonstrated overexpression of Op18/stathmin mRNA in the malignant cancers. Immunohistochemistry showed an apparent overexpression of Op18/stathmin protein level and an association with proliferating cells.

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The phosphoprotein Op18/stathmin is differentially expressed in ovarian cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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