TY - JOUR
T1 - The risk factors and prognosis of bilateral primary breast cancer
T2 - A comparative study with unilateral breast cancer
AU - Wang, Tong
AU - Liu, Hong
AU - Chen, Ke Xin
AU - Xun, Pei
AU - Li, Hai Xin
AU - Tang, Shou Ching
PY - 2011
Y1 - 2011
N2 - This study was performed to determine the risk factors and evaluate the outcome of bilateral breast cancer (BBC). We reviewed the records of 170 patients with BBC and 1,677 with unilateral breast cancer (UBC), and compared their personal history, histopatholgical characteristics, clinical findings, and treatment, and postoperative follow-up records. The patients with UBC were more likely to develop contralateral cancer with the features including: young age at onset, especially younger than 40, premenopause, late primiparity, breast cancer family history, benign mammary disease history, and a tumor larger than 5 cm (p < 0.05). After adjustment by multivariate analysis, we concluded that breast cancer family history and age at onset younger than 40 years old were the independent risk factors for BBC. There were no significant differences for distant metastasis or overall survival between BBC and UBC (p > 0.05). We observed that 64.1% of the second breast cancer occurred within 5 years after the operation of the first cancer, and medical examination could improve the early diagnosis of the contralateral breast cancer. Contrary to common belief, our study showed that BBC and UBC had similar biological features and prognosis (p > 0.05). The excessive treatment and prophylactic measures may be unnecessary in this seemingly aggressive breast cancer. The patients with UBC younger than 40 or with breast cancer family history should have intensive contralateral breast followup, especially within 5 years after in the initial treatment.
AB - This study was performed to determine the risk factors and evaluate the outcome of bilateral breast cancer (BBC). We reviewed the records of 170 patients with BBC and 1,677 with unilateral breast cancer (UBC), and compared their personal history, histopatholgical characteristics, clinical findings, and treatment, and postoperative follow-up records. The patients with UBC were more likely to develop contralateral cancer with the features including: young age at onset, especially younger than 40, premenopause, late primiparity, breast cancer family history, benign mammary disease history, and a tumor larger than 5 cm (p < 0.05). After adjustment by multivariate analysis, we concluded that breast cancer family history and age at onset younger than 40 years old were the independent risk factors for BBC. There were no significant differences for distant metastasis or overall survival between BBC and UBC (p > 0.05). We observed that 64.1% of the second breast cancer occurred within 5 years after the operation of the first cancer, and medical examination could improve the early diagnosis of the contralateral breast cancer. Contrary to common belief, our study showed that BBC and UBC had similar biological features and prognosis (p > 0.05). The excessive treatment and prophylactic measures may be unnecessary in this seemingly aggressive breast cancer. The patients with UBC younger than 40 or with breast cancer family history should have intensive contralateral breast followup, especially within 5 years after in the initial treatment.
KW - Bilateral breast cancer
KW - Prognosis
KW - Treatment and follow-up
KW - Unilateral breast cancer
UR - http://www.scopus.com/inward/record.url?scp=79952435692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952435692&partnerID=8YFLogxK
U2 - 10.3727/096504011X12935427587966
DO - 10.3727/096504011X12935427587966
M3 - Article
C2 - 21473293
AN - SCOPUS:79952435692
SN - 0965-0407
VL - 19
SP - 171
EP - 178
JO - Oncology Research
JF - Oncology Research
IS - 3-4
ER -