The role of glutathione in renal cortical tissue. effects of diamide on Na+ and GSSG levels, amino acid transport and Na+-K+-ATPase activity

Dennis J. Pillion; Lamar Moree; Hector Rocha; David H. Pashley; Joseph Mendicino; Frederick H. Leibach

doi:10.1007/BF00280276

The role of glutathione in renal cortical tissue. effects of diamide on Na⁺ and GSSG levels, amino acid transport and Na⁺-K⁺-ATPase activity

Dennis J. Pillion, Lamar Moree, Hector Rocha, David H. Pashley, Joseph Mendicino, Frederick H. Leibach

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na⁺-K⁺-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na⁺-dependent and Na⁺-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways.

Original language	English (US)
Pages (from-to)	109-115
Number of pages	7
Journal	Molecular and Cellular Biochemistry
Volume	18
Issue number	2-3
DOIs	https://doi.org/10.1007/BF00280276
State	Published - Dec 1977
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Clinical Biochemistry
Cell Biology

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title = "The role of glutathione in renal cortical tissue. effects of diamide on Na+ and GSSG levels, amino acid transport and Na+-K+-ATPase activity",

abstract = "The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na+-dependent and Na+-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways.",

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AU - Pillion, Dennis J.

AU - Moree, Lamar

AU - Rocha, Hector

AU - Pashley, David H.

AU - Mendicino, Joseph

AU - Leibach, Frederick H.

PY - 1977/12

Y1 - 1977/12

N2 - The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na+-dependent and Na+-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways.

AB - The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na+-dependent and Na+-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways.

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IS - 2-3

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The role of glutathione in renal cortical tissue. effects of diamide on Na⁺ and GSSG levels, amino acid transport and Na⁺-K⁺-ATPase activity

Abstract

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