The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events

E. H. Weiss; A. Mellor; L. Golden; K. Fahrner; E. Simpson; J. Hurst; R. A. Flavell

doi:10.1038/301671a0

The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events

E. H. Weiss, A. Mellor, L. Golden, K. Fahrner, E. Simpson, J. Hurst, R. A. Flavell

Infectious Disease

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Abstract

We have cloned a mutant allele of the H-2K^b gene known as H-2K^bml. DNA sequence analysis of this gene shows that it is the result of an intergenic exchange of DNA (gene conversion) which results in the conversion of a short internal segment of the H-2K^b to the corresponding sequence of another H-2 gene. We suggest that this type of gene conversion is widespread in H-2 genes and that it is a major force in the generation of polymorphism in H-2 genes.

Original language	English (US)
Pages (from-to)	671-674
Number of pages	4
Journal	Nature
Volume	301
Issue number	5902
DOIs	https://doi.org/10.1038/301671a0
State	Published - 1983

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abstract = "We have cloned a mutant allele of the H-2Kb gene known as H-2Kbml. DNA sequence analysis of this gene shows that it is the result of an intergenic exchange of DNA (gene conversion) which results in the conversion of a short internal segment of the H-2Kb to the corresponding sequence of another H-2 gene. We suggest that this type of gene conversion is widespread in H-2 genes and that it is a major force in the generation of polymorphism in H-2 genes.",

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T1 - The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events

AU - Weiss, E. H.

AU - Mellor, A.

AU - Golden, L.

AU - Fahrner, K.

AU - Simpson, E.

AU - Hurst, J.

AU - Flavell, R. A.

PY - 1983

Y1 - 1983

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AB - We have cloned a mutant allele of the H-2Kb gene known as H-2Kbml. DNA sequence analysis of this gene shows that it is the result of an intergenic exchange of DNA (gene conversion) which results in the conversion of a short internal segment of the H-2Kb to the corresponding sequence of another H-2 gene. We suggest that this type of gene conversion is widespread in H-2 genes and that it is a major force in the generation of polymorphism in H-2 genes.

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The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events

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