TY - JOUR
T1 - Total and differential white blood cell counts, high-sensitivity C-reactive protein, and the metabolic syndrome in non-affective psychoses
AU - Miller, Brian J.
AU - Mellor, Andrew
AU - Buckley, Peter
N1 - Funding Information:
Dr. Buckley received Grant/research support from the National Institute of Mental Health, Janssen Pharmaceutica, Pfizer, and Sunovion, and is a Consultant (Honorarium/Expenses) for the National Institute of Mental Health.
Funding Information:
Dr. Miller is a recipient of the U.S. National Institutes of Health Clinical Loan Repayment Program. In the past 3 years, he has received: Grant support from the GHSU Intramural Scientist Training Program, the GHSU Brain & Behavior and Immunotherapy Discovery Institutes, the University of Oulu (Finland), the Thule Institute of the University of Oulu, and Oy H. Lundbeck Ab; Consultancy fees for surveys from Medefied Europe and Plaza Research, on behalf of Genetech/Roche; speaker fees for grand rounds lectures from the Maryland Psychiatric Research Center and the Texas A&M University and Scott and White Hospital Department of Psychiatry; travel/accommodations/meeting expenses from the National Institute of Mental Health New Clinical Drug Evaluation Unit New Investigator Award, and the American College of Psychiatrists Laughlin Fellowship; Payment for a survey from e-Rewards Medical Market Research and an award from the Georgia Psychiatric Physicians Association Resident Research Competition. Dr. Mellor received funding support from the NIH (AI083005, AI075165), the Juvenile Diabetes Research Foundation, and the Carlos and Marguerite Mason Trust.
PY - 2013/7
Y1 - 2013/7
N2 - The metabolic syndrome is highly prevalent in patients with schizophrenia, and is associated with a state of chronic, low-grade inflammation. Schizophrenia is also associated with increased inflammation, including aberrant blood levels of pro-inflammatory cytokines and high-sensitivity C-reactive protein (hsCRP). The purpose of this study is to investigate the relationship between total and differential white blood cell (WBC) counts, hsCRP, and the metabolic syndrome in patients with schizophrenia and related non-affective psychoses. Fifty-nine inpatients and outpatients age 18-70 with non-affective psychotic disorders and 22 controls participated in this cross-sectional study. Subjects had a fasting blood draw between 8 and 9. am for glucose, lipids, total and differential WBC counts, and hsCRP. Vital signs and anthropometric measures were obtained. Patients with non-affective psychosis and the metabolic syndrome had significantly higher total WBC counts, monocytes, and hsCRP levels than patients without the metabolic syndrome (p≤. 0.04 for each). In binary logistic regression analyses, after controlling for potential confounding effects of age, race, sex, age at first hospitalization for psychosis, parental history of diabetes, smoking, and psychotropic medications, total WBC count, monocytes, and hsCRP were significant predictors of metabolic syndrome in patients (p≤. 0.04 for each). hsCRP was also a significant predictor of increased waist circumference and triglycerides in patients (p≤. 0.05 for each). Our findings suggest that measurement of total and differential WBC counts and hsCRP blood levels may be germane to the clinical care of patients with schizophrenia and related disorders, and support an association between inflammation and metabolic disturbance in these patients.
AB - The metabolic syndrome is highly prevalent in patients with schizophrenia, and is associated with a state of chronic, low-grade inflammation. Schizophrenia is also associated with increased inflammation, including aberrant blood levels of pro-inflammatory cytokines and high-sensitivity C-reactive protein (hsCRP). The purpose of this study is to investigate the relationship between total and differential white blood cell (WBC) counts, hsCRP, and the metabolic syndrome in patients with schizophrenia and related non-affective psychoses. Fifty-nine inpatients and outpatients age 18-70 with non-affective psychotic disorders and 22 controls participated in this cross-sectional study. Subjects had a fasting blood draw between 8 and 9. am for glucose, lipids, total and differential WBC counts, and hsCRP. Vital signs and anthropometric measures were obtained. Patients with non-affective psychosis and the metabolic syndrome had significantly higher total WBC counts, monocytes, and hsCRP levels than patients without the metabolic syndrome (p≤. 0.04 for each). In binary logistic regression analyses, after controlling for potential confounding effects of age, race, sex, age at first hospitalization for psychosis, parental history of diabetes, smoking, and psychotropic medications, total WBC count, monocytes, and hsCRP were significant predictors of metabolic syndrome in patients (p≤. 0.04 for each). hsCRP was also a significant predictor of increased waist circumference and triglycerides in patients (p≤. 0.05 for each). Our findings suggest that measurement of total and differential WBC counts and hsCRP blood levels may be germane to the clinical care of patients with schizophrenia and related disorders, and support an association between inflammation and metabolic disturbance in these patients.
KW - C-reactive protein
KW - Inflammation
KW - Lymphocytes
KW - Metabolic syndrome
KW - Monocytes
KW - Non-affective psychosis
KW - Schizophrenia
KW - WBC
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UR - http://www.scopus.com/inward/citedby.url?scp=84878156347&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2012.08.016
DO - 10.1016/j.bbi.2012.08.016
M3 - Article
C2 - 22982547
AN - SCOPUS:84878156347
SN - 0889-1591
VL - 31
SP - 82
EP - 89
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
ER -