Tracking Trends in Secondary Stroke Prevention Strategies

Jody L. Carswell, Kemberley A. Beard, Michele M. Chevrette, Carol N. Pardue, David C. Hess, Susan C. Fagan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


BACKGROUND: Stroke is defined as a rapid onset of isolated neurologic dysfunction and is the leading cause of disability in adults, as well as the third-leading cause of death in the US. Nearly 600 000 cases of stroke are reported annually. OBJECTIVE: To quantify the impact of emerging evidence on the use of secondary stroke prevention strategies in patients discharged from a specialized stroke center in 2002 compared with those discharged in 2000. METHODS: Using a retrospective approach, data were collected on the first 100 patients cared for by the stroke service from July 1, 2000, to December 31, 2000. Using a prospective approach, the goal was to enroll 100 patients with a diagnosis of ischemic stroke and telephone the patients 1 and 3 months after discharge to determine patient adherence and persistence rate of medications. This is an interim report of the first 20 patients enrolled. RESULTS: Both studies resulted in populations of 55% women and 45% men. The most common risk factor was hypertension, with 59% on admission in 2000 and 75% in 2002. Use of antithrombotics (98% in 2000 to 100% in 2002) and antihypertensives (67% in 2000 to 90% in 2002) was high in both studies and not significantly different. The 2 most significant changes in prescribing were increased use of statins (13% in 2000 to 50% in 2002, p = 0.0007) and combination clopidogrel and aspirin use (0% in 2000 to 20% in 2002, p = 0.001). At 3 months, 66.7% of patients were on the same antithrombotic medication as at discharge. CONCLUSIONS: The dedicated stroke service was able to effectively translate emerging evidence and guidelines into practice and significantly change the use of prescribed medications for secondary stroke prevention.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalAnnals of Pharmacotherapy
Issue number2
StatePublished - Feb 2004


  • Antihypertensives
  • Antithrombotics
  • Hypertension
  • Statins
  • Stroke prevention

ASJC Scopus subject areas

  • Pharmacology (medical)


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