Treatment trends for advanced oropharyngeal squamous cell carcinoma in the era of human papillomavirus

Faris A. Mirza, Christopher Z. Johnson, James Kenneth Byrd, William Greer Albergotti

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Given recent increase in prevalence of oropharyngeal squamous cell carcinoma (OPSCC) and advances in surgical capabilities, we sought to determine whether a change in frequency of surgery-based treatment for locally advanced OPSCC has occurred. Methods: Patients with T3-T4b OPSCC in the National Cancer Database diagnosed from 2010 to 2016 were categorized as receiving primary surgery or radiation-based therapy and stratified by human papillomavirus (HPV) status. Trends in treatment selection and factors associated with treatment type were examined. Results: 6566 patients with HPV-positive were included, of whom 489 (7.45%) received surgery and 4698 patients with HPV-negative, of whom 362 (7.71%) received surgery. The percentage of patients treated with surgery decreased from 11.8% to 5.9% for HPV-positive disease and from 9.8% to 6.3% for HPV-negative disease. Factors associated with surgery included younger age, health insurance, and treatment at academic centers. Conclusions: In HPV-positive and HPV-negative disease, the percentage of locally advanced OPSCC undergoing surgery-based therapy has decreased.

Original languageEnglish (US)
Pages (from-to)3476-3492
Number of pages17
JournalHead and Neck
Issue number11
StatePublished - Nov 2021


  • chemoradiation
  • human papillomavirus
  • oropharynx
  • squamous cell carcinoma
  • transoral robotic surgery

ASJC Scopus subject areas

  • Otorhinolaryngology


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