TY - JOUR
T1 - Two-way communication between the nucleus and mitochondria via a micropeptide in renal fibrosis
AU - Cai, Juan
AU - Dong, Zheng
N1 - Publisher Copyright:
© 2023
PY - 2023/5
Y1 - 2023/5
N2 - Micropeptides are small proteins encoded by short open reading frames mostly located in long noncoding RNAs. Mitoregulin (MOXI) is a nuclear encoded micropeptide initially identified in the inner mitochondrial membrane to regulate fatty acid β-oxidation. In this issue of Kidney International, Li et al. report that MOXI is upregulated in both human fibrotic kidneys and murine models of renal fibrosis. Remarkably, MOXI functions in the nucleus, where it forms a transcriptional complex with N-acetyltransferase 14 and c-Jun to facilitate the expression of fibrotic genes. By working in the nucleus and mitochondria, MOXI may channel the 2-way communication between these organelles, adding a new layer of complexity in the cell biology of renal fibrogenesis.
AB - Micropeptides are small proteins encoded by short open reading frames mostly located in long noncoding RNAs. Mitoregulin (MOXI) is a nuclear encoded micropeptide initially identified in the inner mitochondrial membrane to regulate fatty acid β-oxidation. In this issue of Kidney International, Li et al. report that MOXI is upregulated in both human fibrotic kidneys and murine models of renal fibrosis. Remarkably, MOXI functions in the nucleus, where it forms a transcriptional complex with N-acetyltransferase 14 and c-Jun to facilitate the expression of fibrotic genes. By working in the nucleus and mitochondria, MOXI may channel the 2-way communication between these organelles, adding a new layer of complexity in the cell biology of renal fibrogenesis.
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U2 - 10.1016/j.kint.2023.02.009
DO - 10.1016/j.kint.2023.02.009
M3 - Comment/debate
C2 - 37085255
AN - SCOPUS:85152141808
SN - 0085-2538
VL - 103
SP - 833
EP - 835
JO - Kidney International
JF - Kidney International
IS - 5
ER -