Abstract
Despite years of research, epilepsy remains a poorly understood disorder. In the past several years, work has been conducted on a variety of projects with the goal of better understanding the pathogenesis and progression of mesial temporal lobe epilepsy (MTLE), in particular, and how to exploit those properties to generate innovative therapies for treatment of refractory epilepsies. This review seeks to give an overview of common morphological and biochemical changes associated with epilepsy and proposed treatments to address those changes. Furthering the understanding of ictogenesis and epileptogenesis remains an important goal for scientists seeking to find more effective treatments for MTLE.
Original language | English (US) |
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Pages (from-to) | 913-924 |
Number of pages | 12 |
Journal | Journal of Neuroscience Research |
Volume | 90 |
Issue number | 5 |
DOIs | |
State | Published - May 2012 |
Externally published | Yes |
Keywords
- Calpain
- Cytokines
- Epileptogenesis
- Temporal lobe epilepsy
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience