TY - JOUR
T1 - Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice
AU - Trantham-Davidson, Heather
AU - Vazdarjanova, Almira
AU - Dai, Rujuan
AU - Terry, Alvin
AU - Bergson, Clare
PY - 2008/6/3
Y1 - 2008/6/3
N2 - Gene linkage and association studies have implicated the region of chromosome 10q containing the calcyon locus with attention deficit hyperactivity disorder (ADHD), bipolar disorder, and schizophrenia susceptibility. In addition, levels of calcyon protein and transcripts are also significantly increased in postmortem tissue from schizophrenic brains. But whether altered calcyon expression might be part of the disease etiology or merely a patho-physiological side effect is not known. To begin to address this issue, we generated a transgenic mouse line (CalOE) using the human calcyon cDNA in which calcyon expression is up-regulated in a number of forebrain structures including the hippocampus, prefrontal cortex (PFC), striatum, and amygdala. Compared to control littermates, the CalOE mice display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety, and/or impaired restraint (harm avoidance) that would indicate that calcyon up-regulation leads to deficits in control over behavioral output.
AB - Gene linkage and association studies have implicated the region of chromosome 10q containing the calcyon locus with attention deficit hyperactivity disorder (ADHD), bipolar disorder, and schizophrenia susceptibility. In addition, levels of calcyon protein and transcripts are also significantly increased in postmortem tissue from schizophrenic brains. But whether altered calcyon expression might be part of the disease etiology or merely a patho-physiological side effect is not known. To begin to address this issue, we generated a transgenic mouse line (CalOE) using the human calcyon cDNA in which calcyon expression is up-regulated in a number of forebrain structures including the hippocampus, prefrontal cortex (PFC), striatum, and amygdala. Compared to control littermates, the CalOE mice display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety, and/or impaired restraint (harm avoidance) that would indicate that calcyon up-regulation leads to deficits in control over behavioral output.
KW - ADHD
KW - Anxiety
KW - Disease model
KW - Impulsivity
KW - Novelty seeking
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=41149168533&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41149168533&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2007.12.031
DO - 10.1016/j.bbr.2007.12.031
M3 - Article
C2 - 18295356
AN - SCOPUS:41149168533
SN - 0166-4328
VL - 189
SP - 244
EP - 249
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 2
ER -