@article{daabdfec964c4d2d9afc6cc5b4011ab1,
title = "Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection",
abstract = "Palivizumab was licensed in June 1998 by the Food and Drug Administration for the reduction of serious lower respiratory tract infection caused by respiratory syncytial virus (RSV) in children at increased risk of severe disease. Since that time, the American Academy of Pediatrics has updated its guidance for the use of palivizumab 4 times as additional data became available to provide a better understanding of infants and young children at greatest risk of hospitalization attributable to RSV infection. The updated recommendations in this policy statement reflect new information regarding the seasonality of RSV circulation, palivizumab pharmacokinetics, the changing incidence of bronchiolitis hospitalizations, the effect of gestational age and other risk factors on RSV hospitalization rates, the mortality of children hospitalized with RSV infection, the effect of prophylaxis on wheezing, and palivizumab-resistant RSV isolates. This policy statement updates and replaces the recommendations found in the 2012 Red Book.",
keywords = "Bronchiolitis, Chronic lung disease, Congenital heart disease, Infants and young children, Palivizumab, RSV, Respiratory syncytial virus",
author = "Brady, {Michael T.} and Byington, {Carrie L.} and Davies, {H. Dele} and Edwards, {Kathryn M.} and Jackson, {Mary Anne} and Maldonado, {Yvonne A.} and Murray, {Dennis L} and Orenstein, {Walter A.} and Rathore, {Mobeen H.} and Sawyer, {Mark H.} and Schutze, {Gordon E.} and Willoughby, {Rodney E.} and Zaoutis, {Theoklis E.} and Bernstein, {Henry H.} and Kimberlin, {David W.} and Long, {Sarah S.} and Meissner, {H. Cody} and Fischer, {Marc A.} and Gellin, {Bruce G.} and Gorman, {Richard L.} and Lee, {Lucia H.} and Pratt, {R. Douglas} and Read, {Jennifer S.} and Robinson, {Joan L.} and Safadi, {Marco Aurelio Palazzi} and Seward, {Jane F.} and Starke, {Jeffrey R.} and Simon, {Geoffrey R.} and Tan, {Tina Q.} and Bocchini, {Joseph A.} and Morrow, {W. Robert} and Pickering, {Larry K.} and Rosenthal, {Geoffrey L.} and Stewart, {Dan L.} and Almut Winterstein and Frantz, {Jennifer M.} and Ralston, {Shawn L.} and Lieberthal, {Allan S.} and Alverson, {Brian K.} and Baley, {Jill E.} and Gadomski, {Anne M.} and Johnson, {David W.} and Light, {Michael J.} and Maraqa, {Nizar F.} and Mendonca, {Eneida A.} and Phelan, {Kieran J.} and Zorc, {Joseph J.} and Danette Stanko-Lopp and Sinsi Hern{\'a}ndez-Cancio and Brown, {Mark A.} and Ian Nathanson and Elizabeth Rosenblum and Stephen Sayles and Caryn Davidson",
year = "2014",
month = aug,
day = "1",
doi = "10.1542/peds.2014-1665",
language = "English (US)",
volume = "134",
pages = "415--420",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "2",
}