Urinary excretion of vasoactive factors are correlated to sodium excretion

Robert W. Jackson, Frank A. Treiber, Gregory A Harshfield, Jennifer L. Waller, Jennifer S. Pollock, David M. Pollock

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background: The relationship between urinary vasoactive factors and sodium excretion has not been adequately addressed in humans. Procedure: Excretion rates of sodium, nitrates/nitrites (NOx), cGMP, and endothelin-1 (ET-1) were measured before and after ingestion of a mixed electrolyte solution (8 oz Gatorade) while undergoing a routine cardiovascular evaluation in a sample of 51 normotensive young adults. Results: Significant correlations were detected for changes in excretion between all four variables, r ranged from 0.50 to 0.86 (P < .001). Correlations were higher in African Americans than white Americans. Conclusions: The association of renal ET-1 and NO activity with sodium excretion supports the hypothesis that these factors play a role in the physiologic response to acute changes in sodium intake, particularly in African Americans.

Original languageEnglish (US)
Pages (from-to)1003-1006
Number of pages4
JournalAmerican journal of hypertension
Issue number10
StatePublished - 2001


  • Endothelin-1
  • Ethnicity
  • Nitric oxide
  • Renal
  • Sodium

ASJC Scopus subject areas

  • Internal Medicine


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