Use of tray-applied 10 percent carbamide peroxide gels for improving oral health in patients with special-care needs

David A. Lazarchik, Haywood Van B

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background. Plaque accumulation and resulting caries or periodontal disease is a frequent problem in patients with special-care needs. Trayapplied 10 percent carbamide peroxide (CP) is a tooth-bleaching agent that has positive effects on plaque, gingival health and caries. Methods. The authors review the antibacterial properties of CP and the effects of CP on saliva, plaque, caries and gingival health. They also review tray fabrication options and techniques, application methods, safety and side effects. Finally, they address the challenges involved in and research needed regarding use of tray-applied CP materials in special-care patients. Results. In their literature review and clinical experience, the authors found 10 percent CP delivered in a custom-fitted tray to be an effective treatment for caries in patients with compromised oral hygiene. Plaque suppression and caries control result from a CP-induced increase in salivary and plaque pH caused by CPs urea component, and from possible antimicrobial action via physical debridement and the direct chemical effect of hydrogen peroxide. Conclusions. Tray-applied 10 percent CP may hold great promise for improving the oral health of many special-care patients, including elderly patients, patients with cancer and patients with dry mouth. Further research is needed to verify the potential benefits, specifics of treatment times and protocols and most cost-effective products for use in various patient groups. Clinical Implications. Application of 10 percent CP in a customfitted tray may reduce caries by elevating the pH above the level at which the caries process can occur, in addition to debriding the teeth and improving gingival health.

Original languageEnglish (US)
Pages (from-to)639-646
Number of pages8
JournalJournal of the American Dental Association
Issue number6
StatePublished - Jun 2010


  • Carbamide peroxide
  • Caries control
  • Dental plaque
  • Peroxides
  • Tooth bleaching
  • Urea

ASJC Scopus subject areas

  • Dentistry(all)


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