TY - JOUR
T1 - Validation of the mechanisms proposed for the stimulatory and inhibitory effects of progesterone on gonadotropin secretion in the estrogenprimed rat
T2 - a possible role for adrenal steroids
AU - Brann, Darrell W.
AU - Putnam, Caria D.
AU - Mahesh, Virendra B.
N1 - Funding Information:
Supported by Research Grant HD 16688,N ICHHD, National Institutes of Health, US Public Health Service.
PY - 1991/2
Y1 - 1991/2
N2 - The stimulatory and inhibitory effects of progesterone on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion were found to be dependent on the length of estrogen exposure in ovariectomized estrogen-primed rats. Progesterone suppressed LH and FSH secretion when administered 16 hours after a single infection of estradiol to ovariectomized rats. If the estradiol treatment was extended over 40 hours by two injections ofestradiol 24 hours apart, progesterone administration led to a highly significant elevation of both serum LH and FSH levels 6 hours later. In addition to the direct stimulatory effect on LH and FSH release, progesterone, when injected I hour before, was able to antagonize the suppressive effect of a third injection of estradiol on LH and FSH release. In the immature ovariectomized estrogen-primed rat, 10 IU of ACTH brought about a release of progesterone and corticosterone 15 minutes later and LH and FSH 6 hours later. Progesterone, but not corticosterone, appeared to be responsible for the effect of ACTH on gonadotropin release. The synthetic corticosteroid triamcinolone acetonide brought about LH and FSH release in the afternoon, while cortisol, similar to corticosterone, was unable to do so. Nevertheless, triamcinolone acetonide and cortisol brought about increased secretion of FSH the following morning.
AB - The stimulatory and inhibitory effects of progesterone on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion were found to be dependent on the length of estrogen exposure in ovariectomized estrogen-primed rats. Progesterone suppressed LH and FSH secretion when administered 16 hours after a single infection of estradiol to ovariectomized rats. If the estradiol treatment was extended over 40 hours by two injections ofestradiol 24 hours apart, progesterone administration led to a highly significant elevation of both serum LH and FSH levels 6 hours later. In addition to the direct stimulatory effect on LH and FSH release, progesterone, when injected I hour before, was able to antagonize the suppressive effect of a third injection of estradiol on LH and FSH release. In the immature ovariectomized estrogen-primed rat, 10 IU of ACTH brought about a release of progesterone and corticosterone 15 minutes later and LH and FSH 6 hours later. Progesterone, but not corticosterone, appeared to be responsible for the effect of ACTH on gonadotropin release. The synthetic corticosteroid triamcinolone acetonide brought about LH and FSH release in the afternoon, while cortisol, similar to corticosterone, was unable to do so. Nevertheless, triamcinolone acetonide and cortisol brought about increased secretion of FSH the following morning.
KW - adrenal, role in regulation of gonadotropin release
KW - antagonism of estrogen action by progesterone
KW - follicle-stimulating hormone
KW - luteinizing hormone
KW - progesterone, effects on gonadotropin release
KW - steroids
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U2 - 10.1016/0039-128X(91)90132-F
DO - 10.1016/0039-128X(91)90132-F
M3 - Article
C2 - 1850562
AN - SCOPUS:0025857623
SN - 0039-128X
VL - 56
SP - 103
EP - 111
JO - Steroids
JF - Steroids
IS - 2
ER -