TY - JOUR
T1 - Vascular effects of free radicals generated by electrical stimulation.
AU - Lamb, F. S.
AU - Webb, R. C.
PY - 1984/11/1
Y1 - 1984/11/1
N2 - Electrical field stimulation (9 V, 1.0 ms, 4 Hz) of isolated segments of rat tail arteries and dog coronary arteries inhibits contractile responses to exogenous norepinephrine and elevated potassium concentration. This inhibitory effect of electrical stimulation is blocked by various agents that alter oxygen metabolism: superoxide dismutase, catalase, glutathione, ascorbate, and dimethyl sulfoxide. The observations suggest that the inhibitory effect is due to an action of oxygen free radical metabolites that are generated by the electrical stimulation of the oxygen-rich buffer. These free radical metabolites have two actions: 1) they oxidize drugs in the experimental system, and 2) they exert a direct inhibitory action on vascular smooth muscle.
AB - Electrical field stimulation (9 V, 1.0 ms, 4 Hz) of isolated segments of rat tail arteries and dog coronary arteries inhibits contractile responses to exogenous norepinephrine and elevated potassium concentration. This inhibitory effect of electrical stimulation is blocked by various agents that alter oxygen metabolism: superoxide dismutase, catalase, glutathione, ascorbate, and dimethyl sulfoxide. The observations suggest that the inhibitory effect is due to an action of oxygen free radical metabolites that are generated by the electrical stimulation of the oxygen-rich buffer. These free radical metabolites have two actions: 1) they oxidize drugs in the experimental system, and 2) they exert a direct inhibitory action on vascular smooth muscle.
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U2 - 10.1152/ajpheart.1984.247.5.h709
DO - 10.1152/ajpheart.1984.247.5.h709
M3 - Article
C2 - 6496752
AN - SCOPUS:0021522756
SN - 0002-9513
VL - 247
SP - H709-H714
JO - The American journal of physiology
JF - The American journal of physiology
IS - 5 Pt 2
ER -