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Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter

  • Dan C. Martin(corresponding author)
    ,
  • Robert P. Introna
    ,
  • Robert S. Aronstam
*Corresponding author for this work
Scholary Output:
Contribution to journal
Article
 Peer-review

Abstract

The effects of halothane and ketamine on (1) serotonin (5-hydroxytryptamine; 5-HT) uptake and (2) paroxetine binding to the 5-HT transporter in neuronal membranes were determined in rat brain. Both anesthetics inhibited the uptake of [3H]5-HT by synaptosomes, but only ketamine affected binding of [3H]paroxetine to the 5-HT transporter. Saturation analysis indicated that ketamine inhibition of [3H]paroxetine binding was competitive (Ki = 18.8 μM). These results indicate that halothane and ketamine inhibit 5-HT transport by different mechanisms.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 99-103 (5 pages)

Journal (Volume, Issue Number)

Neuroscience Letters (Volume 112, Issue 1)

Publication milestones

  • Published - 04/20/1990

Publication status

Published - 04/20/1990

ISSN

0304-3940

Publication IDs

  • Scopus: 0025318248
  • PubMed: 2143567

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Funding Details

This work was supportedb y a 1988B .B. SankeyA nesthesiaA dvancemenAtw ard from the InternationaAln esthesiaR esearchS ocietya nd by a grant from the Georgia Affiliate of the AmericanH eartAssociation.
FundersFunding numbers
InternationaAln esthesiaR esearchS ocietya
-
National and Georgia Affiliate American Heart Association
-
AmericanH eartAssociation
-