Marco Orecchioni

2024

Olfr2-positive macrophages originate from monocytes proliferate in situ and present a pro-inflammatory foamy-like phenotype

Suthahar, S. S. A., Nettersheim, F. S., Alimadadi, A., Wang, E., Billitti, M., Resto-Trujillo, N., Roy, P., Hedrick, C., Ley, K. & Orecchioni, M., Sep 1 2024, In: Cardiovascular Research. 120, 13, p. 1577-1589 13 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling

Frias-Anaya, E., Gallego-Gutierrez, H., Gongol, B., Weinsheimer, S., Lai, C. C., Orecchioni, M., Sriram, A., Bui, C. M., Nelsen, B., Hale, P., Pham, A., Shenkar, R., Debiasse, D., Lightle, R., Girard, R., Li, Y., Srinath, A., Daneman, R., Nudleman, E. & Sun, H. & 8 others, Guma, M., Dubrac, A., Mesarwi, O. A., Ley, K., Kim, H., Awad, I. A., Ginsberg, M. H. & Lopez-Ramirez, M. A., Jun 1 2024, In: Arteriosclerosis, thrombosis, and vascular biology. 44, 6, p. 1246-1264 19 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Immune profiling and tracking of two-dimensional transition metal dichalcogenides in cells and tissues

Gazzi, A., Fusco, L., Orecchioni, M., Keshavan, S., Shin, Y., Grivel, J. C., Rinchai, D., Ahmed, E. I., Elhanani, O., Furesi, G., Rauner, M., Keren, L., Ley, K., Casiraghi, C., Bedognetti, D., Fadeel, B. & Delogu, L. G., Feb 2024, In: Nano Today. 54, 102084.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Nanoplastics: Immune Impact, Detection, and Internalization after Human Blood Exposure by Single-Cell Mass Cytometry

Fusco, L., Gazzi, A., Giro, L., Schefer, R. B., D'Almeida, S. M., Cagliani, R., Zoccheddu, M., Uyar, R., Besbinar, Ö., Çelik, D., Yilmazer, A., Mitrano, D. M., Orecchioni, M. & Delogu, L. G., 2024, (Accepted/In press) In: Advanced Materials.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Identification of human exT_reg cells as CD16⁺CD56⁺ cytotoxic CD4⁺ T cells

Freuchet, A., Roy, P., Armstrong, S. S., Oliaeimotlagh, M., Kumar, S., Orecchioni, M., Ali, A. J., Khan, A., Makings, J., Lyu, Q., Winkels, H., Wang, E., Durant, C., Ghosheh, Y., Gulati, R., Nettersheim, F. & Ley, K., Oct 2023, In: Nature Immunology. 24, 10, p. 1748-1761 14 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation

Gupta, G., Kaur, J., Bhattacharya, K., Chambers, B. J., Gazzi, A., Furesi, G., Rauner, M., Fuoco, C., Orecchioni, M., Delogu, L. G., Haag, L., Stehr, J. E., Thomen, A., Bordes, R., Malmberg, P., Seisenbaeva, G. A., Kessler, V. G., Persson, M. & Fadeel, B., Sep 12 2023, In: ACS Nano. 17, 17, p. 17451-17467 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

V₄C₃ MXene Immune Profiling and Modulation of T Cell-Dendritic Cell Function and Interaction

Fusco, L., Gazzi, A., Shuck, C. E., Orecchioni, M., Ahmed, E. I., Giro, L., Zavan, B., Yilmazer, A., Ley, K., Bedognetti, D., Gogotsi, Y. & Delogu, L. G., Aug 18 2023, In: Small Methods. 7, 8, 2300197.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe ^−/− mice

Orecchioni, M., Wolf, D., Suryawanshi, V., Winkels, H., Kobiyama, K., Makings, J., Kiosses, W. B. & Ley, K., Jan 2023, In: Cellular and Molecular Life Sciences. 80, 1, 10.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2022

Graphene nanoribbons are internalized by human primary immune cell subpopulations maintaining a safety profile: A high-dimensional pilot study by single-cell mass cytometry

Fuoco, C., Luan, X., Fusco, L., Riccio, F., Giuliani, G., Lin, H., Orecchioni, M., Martín, C., Cesareni, G., Feng, X., Mai, Y., Bianco, A. & Delogu, L. G., Dec 2022, In: Applied Materials Today. 29, 101593.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Titration of 124 antibodies using CITE-Seq on human PBMCs

Nettersheim, F. S., Armstrong, S. S., Durant, C., Blanco-Dominguez, R., Roy, P., Orecchioni, M., Suryawanshi, V. & Ley, K., Dec 2022, In: Scientific reports. 12, 1, 20817.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease

Lai, C. C., Nelsen, B., Frias-Anaya, E., Gallego-Gutierrez, H., Orecchioni, M., Herrera, V., Ortiz, E., Sun, H., Mesarwi, O. A., Ley, K., Gongol, B. & Lopez-Ramirez, M. A., Nov 11 2022, In: Circulation research. 131, 11, p. 909-925 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Immune Profiling and Multiplexed Label-Free Detection of 2D MXenes by Mass Cytometry and High-Dimensional Imaging

Fusco, L., Gazzi, A., Shuck, C. E., Orecchioni, M., Alberti, D., D'Almeida, S. M., Rinchai, D., Ahmed, E., Elhanani, O., Rauner, M., Zavan, B., Grivel, J. C., Keren, L., Pasqual, G., Bedognetti, D., Ley, K., Gogotsi, Y. & Delogu, L. G., Nov 10 2022, In: Advanced Materials. 34, 45, 2205154.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Immunodominant MHC-II (Major Histocompatibility Complex II) Restricted Epitopes in Human Apolipoprotein B

Roy, P., Sidney, J., Lindestam Arlehamn, C. S., Phillips, E., Mallal, S., Armstrong Suthahar, S. S., Billitti, M., Rubiro, P., Marrama, D., Drago, F., Vallejo, J., Suryawanshi, V., Orecchioni, M., Makings, J., Kim, P. J., McNamara, C. A., Peters, B., Sette, A. & Ley, K., Jul 22 2022, In: Circulation research. 131, 3, p. 258-276 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

A humanized β₂ integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in vivo

Wen, L., Marki, A., Wang, Z., Orecchioni, M., Makings, J., Billitti, M., Wang, E., Suthahar, S. S. A., Kim, K., Kiosses, W. B., Mikulski, Z. & Ley, K., May 31 2022, In: Cell Reports. 39, 9, 110876.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease

Saigusa, R., Roy, P., Freuchet, A., Gulati, R., Ghosheh, Y., Armstrong Suthahar, S. S., Durant, C. P., Hanna, D. B., Kiosses, W. B., Orecchioni, M., Wen, L., Wu, R., Kuniholm, M. H., Landay, A. L., Anastos, K., Tien, P. C., Gange, S. J., Kassaye, S., Vallejo, J. & Hedrick, C. C. & 5 others, Kwok, W. W., Sette, A., Hodis, H. N., Kaplan, R. C. & Ley, K., May 2022, In: Nature Cardiovascular Research. 1, 5, p. 462-475 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice

Fan, Z., Pitmon, E., Wen, L., Miller, J., Ehinger, E., Herro, R., Liu, W., Chen, J., Mikulski, Z., Conrad, D. J., Marki, A., Orecchioni, M., Kumari, P., Zhu, Y. P., Marcovecchio, P. M., Hedrick, C. C., Hodges, C. A., Rathinam, V. A., Wang, K. & Ley, K., Feb 1 2022, In: Journal of Immunology. 208, 3, p. 745-752 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production

Orecchioni, M., Kobiyama, K., Winkels, H., Ghosheh, Y., McArdle, S., Mikulski, Z., Kiosses, W. B., Fan, Z., Wen, L., Jung, Y., Roy, P., Ali, A. J., Miyamoto, Y., Mangan, M., Makings, J., Wang, Z., Denn, A., Vallejo, J., Owens, M. & Durant, C. P. & 9 others, Braumann, S., Mader, N., Li, L., Matsunami, H., Eckmann, L., Latz, E., Wang, Z., Hazen, S. L. & Ley, K., Jan 14 2022, In: Science. 375, 6577, p. 214-221 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

120 Scopus citations

Graphene oxide activates B cells with upregulation of granzyme B expression: Evidence at the single-cell level for its immune-modulatory properties and anticancer activity

Orecchioni, M., Fusco, L., Mall, R., Bordoni, V., Fuoco, C., Rinchai, D., Guo, S., Sainz, R., Zoccheddu, M., Gurcan, C., Yilmazer, A., Zavan, B., Ménard-Moyon, C., Bianco, A., Hendrickx, W., Bedognetti, D. & Delogu, L. G., 2022, In: Nanoscale. 14, 2, p. 333-349 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2021

Thymus-Derived CD4⁺CD8⁺ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch

Winkels, H., Ghosheh, Y., Kobiyama, K., Kiosses, W. B., Orecchioni, M., Ehinger, E., Suryawanshi, V., Herrera-De La Mata, S., Marchovecchio, P., Riffelmacher, T., Thiault, N., Kronenberg, M., Wolf, D., Seumois, G., Vijayanand, P. & Ley, K., Dec 1 2021, In: Journal of Immunology. 207, 11, p. 2720-2732 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types

Fusco, L., Orecchioni, M., Reina, G., Bordoni, V., Fuoco, C., Gurcan, C., Guo, S., Zoccheddu, M., Collino, F., Zavan, B., Treossi, E., Yilmazer, A., Palermo, V., Bianco, A. & Delogu, L. G., Jul 2021, In: NanoImpact. 23, 100330.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2D MXenes with antiviral and immunomodulatory properties: A pilot study against SARS-CoV-2

Unal, M. A., Bayrakdar, F., Fusco, L., Besbinar, O., Shuck, C. E., Yalcin, S., Erken, M. T., Ozkul, A., Gurcan, C., Panatli, O., Summak, G. Y., Gokce, C., Orecchioni, M., Gazzi, A., Vitale, F., Somers, J., Demir, E., Yildiz, S. S., Nazir, H. & Grivel, J. C. & 6 others, Bedognetti, D., Crisanti, A., Akcali, K. C., Gogotsi, Y., Delogu, L. G. & Yilmazer, A., Jun 2021, In: Nano Today. 38, 101136.

Research output: Contribution to journal › Article › peer-review

Open Access

90 Scopus citations

Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis

Marki, A., Buscher, K., Lorenzini, C., Meyer, M., Saigusa, R., Fan, Z., Yeh, Y. T., Hartmann, N., Dan, J. M., Kiosses, W. B., Golden, G. J., Ganesan, R., Winkels, H., Orecchioni, M., McArdle, S., Mikulski, Z., Altman, Y., Bui, J., Kronenberg, M. & Chien, S. & 5 others, Esko, J. D., Nizet, V., Smalley, D., Roth, J. & Ley, K., Mar 1 2021, In: Journal of Experimental Medicine. 218, 3, e20200551.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Biocompatibility studies of macroscopic fibers made from carbon nanotubes: Implications for carbon nanotube macrostructures in biomedical applications

Yan, J. S., Orecchioni, M., Vitale, F., Coco, J. A., Duret, G., Antonucci, S., Pamulapati, S. S., Taylor, L. W., Dewey, O. S., Di Sante, M., Segura, A. M., Gurcan, C., Di Lisa, F., Yilmazer, A., McCauley, M. D., Robinson, J. T., Razavi, M., Ley, K., Delogu, L. G. & Pasquali, M., Mar 2021, In: Carbon. 173, p. 462-476 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B

Nettersheim, F. S., Braumann, S., Kobiyama, K., Orecchioni, M., Vassallo, M., Miller, J., Ali, A., Roy, P., Saigusa, R., Wolf, D., Ley, K. & Winkels, H., 2021, In: Frontiers in Cardiovascular Medicine. 8, 812769.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2020

Bioinspired Scaffold Action Under the Extreme Physiological Conditions of Simulated Space Flights: Osteogenesis Enhancing Under Microgravity

Avitabile, E., Fusco, L., Minardi, S., Orecchioni, M., Zavan, B., Yilmazer, A., Rauner, M., Pippia, P., Tasciotti, E. & Delogu, L. G., Jul 8 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 722.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Graphene, other carbon nanomaterials and the immune system: Toward nanoimmunity-by-design

Gazzi, A., Fusco, L., Orecchioni, M., Ferrari, S., Franzoni, G., Yan, J. S., Rieckher, M., Peng, G., Lucherelli, M. A., Vacchi, I. A., Quyen Chau, N. D., Criado, A., Istif, A., Mancino, D., Dominguez, A., Eckert, H., Vázquez, E., Ros, T. D., Nicolussi, P. & Palermo, V. & 13 others, Schumacher, B., Cuniberti, G., Mai, Y., Clementi, C., Pasquali, M., Feng, X., Kostarelos, K., Yilmazer, A., Bedognetti, D., Fadeel, B., Prato, M., Bianco, A. & Delogu, L. G., Jul 2020, In: JPhys Materials. 3, 3, 034009.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Toward High-Dimensional Single-Cell Analysis of Graphene Oxide Biological Impact: Tracking on Immune Cells by Single-Cell Mass Cytometry

Orecchioni, M., Bordoni, V., Fuoco, C., Reina, G., Lin, H., Zoccheddu, M., Yilmazer, A., Zavan, B., Cesareni, G., Bedognetti, D., Bianco, A. & Delogu, L. G., May 1 2020, In: Small. 16, 21, 2000123.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Impact of the surface functionalization on nanodiamond biocompatibility: a comprehensive view on human blood immune cells

Fusco, L., Avitabile, E., Armuzza, V., Orecchioni, M., Istif, A., Bedognetti, D., Da Ros, T. & Delogu, L. G., Apr 30 2020, In: Carbon. 160, p. 390-404 15 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Signaling response to transient redox stress in human isolated T cells: Molecular sensor role of syk kinase and functional involvement of IL2 receptor and L-selectine

Secchi, C., Orecchioni, M., Carta, M., Galimi, F., Turrini, F. & Pantaleo, A., Jan 2 2020, In: Sensors. 20, 2, 466.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2019

Stimulation of bone formation by monocyte-activator functionalized graphene oxide: In vivo

Bordoni, V., Reina, G., Orecchioni, M., Furesi, G., Thiele, S., Gardin, C., Zavan, B., Cuniberti, G., Bianco, A., Rauner, M. & Delogu, L. G., Nov 7 2019, In: Nanoscale. 11, 41, p. 19408-19421 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

In Vivo Restoration of Myocardial Conduction With Carbon Nanotube Fibers

Mccauley, M. D., Vitale, F., Yan, J. S., Young, C. C., Greet, B., Orecchioni, M., Perike, S., Elgalad, A., Coco, J. A., John, M., Taylor, D. A., Sampaio, L. C., Delogu, L. G., Razavi, M. & Pasquali, M., Aug 1 2019, In: Circulation: Arrhythmia and Electrophysiology. 12, 8, 007256.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

High-Affinity Bent β₂-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis

Fan, Z., Kiosses, W. B., Sun, H., Orecchioni, M., Ghosheh, Y., Zajonc, D. M., Arnaout, M. A., Gutierrez, E., Groisman, A., Ginsberg, M. H. & Ley, K., Jan 2 2019, In: Cell Reports. 26, 1, p. 119-130.e5

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

2018

Regulatory CD4⁺ T cells recognize major histocompatibility complex class II molecule-restricted peptide epitopes of apolipoprotein B

Kimura, T., Kobiyama, K., Winkels, H., Tse, K., Miller, J., Vassallo, M., Wolf, D., Ryden, C., Orecchioni, M., Dileepan, T., Jenkins, M. K., James, E. A., Kwok, W. W., Hanna, D. B., Kaplan, R. C., Strickler, H. D., Durkin, H. G., Kassaye, S. G., Karim, R. & Tien, P. C. & 5 others, Landay, A. L., Gange, S. J., Sidney, J., Sette, A. & Ley, K., 2018, In: Circulation. 138, 11, p. 1130-1143 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

2017

Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells

Orecchioni, M., Bedognetti, D., Newman, L., Fuoco, C., Spada, F., Hendrickx, W., Marincola, F. M., Sgarrella, F., Rodrigues, A. F., Ménard-Moyon, C., Cesareni, G., Kostarelos, K., Bianco, A. & G Delogu, L., Dec 1 2017, In: Nature communications. 8, 1, 1109.

Research output: Contribution to journal › Article › peer-review

Open Access

116 Scopus citations

Few-Layer Graphene Kills Selectively Tumor Cells from Myelomonocytic Leukemia Patients

Russier, J., León, V., Orecchioni, M., Hirata, E., Virdis, P., Fozza, C., Sgarrella, F., Cuniberti, G., Prato, M., Vázquez, E., Bianco, A. & Delogu, L. G., Mar 6 2017, In: Angewandte Chemie - International Edition. 56, 11, p. 3014-3019 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

2016

Immune cell impact of three differently coated lipid nanocapsules: Pluronic, chitosan and polyethylene glycol

Farace, C., Sánchez-Moreno, P., Orecchioni, M., Manetti, R., Sgarrella, F., Asara, Y., Peula-García, J. M., Marchal, J. A., Madeddu, R. & Delogu, L. G., Jan 5 2016, In: Scientific reports. 6, 18423.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

Molecular and Genomic Impact of Large and Small Lateral Dimension Graphene Oxide Sheets on Human Immune Cells from Healthy Donors

Orecchioni, M., Jasim, D. A., Pescatori, M., Manetti, R., Fozza, C., Sgarrella, F., Bedognetti, D., Bianco, A., Kostarelos, K. & Delogu, L. G., Jan 1 2016, In: Advanced Healthcare Materials. 5, 2, p. 276-287 12 p.

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Immune compatible cystine-functionalized superparamagnetic iron oxide nanoparticles as vascular contrast agents in ultrasonography

Dolci, S., Domenici, V., Vidili, G., Orecchioni, M., Bandiera, P., Madeddu, R., Farace, C., Peana, M., Tiné, M. R., Manetti, R., Sgarrella, F. & Delogu, L. G., 2016, In: RSC Advances. 6, 4, p. 2712-2723 12 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2014

Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions

Crescio, C., Orecchioni, M., Ménard-Moyon, C., Sgarrella, F., Pippia, P., Manetti, R., Bianco, A. & Delogu, L. G., Aug 21 2014, In: Nanoscale. 6, 16, p. 9599-9603 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Marco Orecchioni

Research output

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