Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice

Keyphrases

• 5-aminolevulinate 33%
• Blood Count 33%
• Butyric Acid 33%
• Cellular Level 33%
• Clinical Usefulness 33%
• Disease Severity 33%
• Drug Toxicity 33%
• Drug Treatment 33%
• Effective Strategies 33%
• EIF2α Kinase 33%
• Erythroid Precursors 100%
• Erythroid Progenitors 100%
• FDA-approved Drugs 33%
• Fetal Hemoglobin 100%
• Flow Cytometry 33%
• Frequent Monitoring 33%
• Gene Transcription 33%
• Globin Expression 33%
• Globin Genes 33%
• Globin Promoter 33%
• HbF Induction 33%
• HbF Level 33%
• Heme 33%
• Heme Biosynthesis 33%
• Hemoglobin Expression 100%
• Histone Acetylation 33%
• Histone H4 Acetylation 33%
• Hydroxyurea 33%
• Inducing Agents 33%
• K562 Cells 33%
• Mouse Model 33%
• Non-responders 33%
• Peripheral Blood Mononuclear Cells 33%
• Pharmacologic 33%
• Potential Development 33%
• Prodrug 100%
• Prodrug Conjugate 33%
• Red Blood Cells 33%
• Sickle Cell Disease 66%
• Toxicity Threshold 33%
• Transgenic Mice 100%

Medicine and Dentistry

• Acetylation 10%
• Aminolevulinic Acid 10%
• Butyric Acid 10%
• Conjugate 10%
• Disease Severity 10%
• Drug Therapy 10%
• Drug Toxicity 10%
• Embryonic Hemoglobin 100%
• Erythrocyte 10%
• Flow Cytometry 10%
• Genetic Transcription 10%
• Globin 20%
• Globin Gene 10%
• Heme 20%
• Histone H3 10%
• Histone H4 10%
• Hydroxyurea 10%
• Initiation Factor 2 10%
• K562 Cells 10%
• Peripheral Blood Mononuclear Cell 10%
• Phosphotransferase 10%
• Precursor 30%
• Prodrug 100%
• Promoter Region 10%
• Sickle-Cell Disease 20%
• Transgenic Mouse 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Aminolevulinic Acid 10%
• Butyrate 10%
• Disease Severity 10%
• Drug Toxicity 10%
• Flow Cytometry 10%
• Globin 30%
• Heme 20%
• Hemoglobin F 100%
• Histone H3 10%
• Histone H4 10%
• Hydroxycarbamide 10%
• Initiation Factor 2 10%
• Mouse Model 10%
• Pharmacotherapy 10%
• Phosphotransferase 10%
• Prodrug 100%
• Sickle Cell Anemia 20%
• Transgenic Mouse 100%