TY - JOUR
T1 - Dances with leukocytes
T2 - How tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms
AU - Ley, Klaus
AU - Zhang, Hong
PY - 2008/11/3
Y1 - 2008/11/3
N2 - Rather than just providing an unstructured adhesive surface for leukocytes, cytokine-activated endothelial cells assemble preexisting tetraspanin-enriched microdomains to form endothelial adhesive platforms (EAPs) and endothelial docking structures. In this issue of the Journal of Cell Biology , Barreiro et al. (Barreiro, O., M. Zamai, M. Yáñez-Mó , E. Tejera, P. López-Romero, P.N. Monk, E. Gratton, V.R. Caiolfa, and F. Sánchez-Madrid. 2008. J. Cell Biol. 183:527-542) show how the immunoglobulin superfamily adhesion molecules intercellular adhesion molecule (ICAM) - 1 and vascular cell adhesion molecule (VCAM) - 1 form nanoclusters with the tetraspanins CD9 and CD151 in a physiologically relevant system. Furthermore, convincing biochemical data suggest that these structures are distinct from lipid rafts.
AB - Rather than just providing an unstructured adhesive surface for leukocytes, cytokine-activated endothelial cells assemble preexisting tetraspanin-enriched microdomains to form endothelial adhesive platforms (EAPs) and endothelial docking structures. In this issue of the Journal of Cell Biology , Barreiro et al. (Barreiro, O., M. Zamai, M. Yáñez-Mó , E. Tejera, P. López-Romero, P.N. Monk, E. Gratton, V.R. Caiolfa, and F. Sánchez-Madrid. 2008. J. Cell Biol. 183:527-542) show how the immunoglobulin superfamily adhesion molecules intercellular adhesion molecule (ICAM) - 1 and vascular cell adhesion molecule (VCAM) - 1 form nanoclusters with the tetraspanins CD9 and CD151 in a physiologically relevant system. Furthermore, convincing biochemical data suggest that these structures are distinct from lipid rafts.
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U2 - 10.1083/jcb.200809173
DO - 10.1083/jcb.200809173
M3 - Comment/debate
C2 - 18981226
AN - SCOPUS:56149110841
SN - 0021-9525
VL - 183
SP - 375
EP - 376
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 3
ER -