Simvastatin-Mediated Nrf2 Activation Induces Fetal Hemoglobin and Antioxidant Enzyme Expression to Ameliorate the Phenotype of Sickle Cell Disease

Agriculture & Biology

• sickle cell anemia 100%
• antioxidant enzymes 60%
• hemoglobin 58%
• phenotype 44%
• oxidative stress 32%
• cystine 30%
• antioxidants 26%
• histones 26%
• glutathione 22%
• iron 19%
• erythroblasts 18%
• antioxidant genes 18%
• abnormal hemoglobin 18%
• coenzyme A 16%
• response elements 16%
• hemolysis 14%
• methyltransferases 14%
• signs and symptoms (animals and humans) 12%
• inflammation 12%
• chromatin 12%
• animal models 11%
• spleen 11%
• lysine 11%
• therapeutics 10%
• transcription factors 10%
• mouth 10%
• genetically modified organisms 10%
• protein synthesis 10%
• transcription (genetics) 10%
• biosynthesis 8%
• liver 7%
• mice 7%
• tissues 6%
• genes 4%

Medicine & Life Sciences

• Fetal Hemoglobin 90%
• Simvastatin 80%
• Sickle Cell Anemia 74%
• Antioxidants 50%
• Phenotype 40%
• Enzymes 37%
• Cystine 29%
• Oxidative Stress 24%
• Glutathione 20%
• Iron 18%
• glutaryl-coenzyme A 17%
• Enhancer of Zeste Homolog 2 Protein 17%
• Antioxidant Response Elements 16%
• Sickle Hemoglobin 15%
• Histone Methyltransferases 15%
• Erythroblasts 14%
• Globins 14%
• Nucleic Acid Regulatory Sequences 13%
• Hemolysis 11%
• Lysine 11%
• Histones 10%
• Oxidoreductases 10%
• Transgenic Mice 10%
• Chromatin 9%
• Genes 9%
• Spleen 8%
• Transcription Factors 8%
• Inflammation 6%
• Liver 5%
• Proteins 4%
• Therapeutics 1%

Chemical Compounds

• Simvastatin 99%
• Hemoglobin 63%
• Antioxidant Agent 51%
• Oxidative Stress 33%
• Cystine 26%
• Histone 24%
• Glutathione 20%
• Coenzyme A 13%
• Enhancer 13%
• Lysine 10%
• Biosynthesis 9%
• Protein 4%